電気キャパシタンス・トモグラフィー法による体外循環血流内の血栓検出法の確立

电容断层扫描体外循环血栓检测方法的建立

基本信息

批准号：
22KF0066
负责人：
武居昌宏
金额：
$ 1.47万
依托单位：
Chiba University
依托单位国家：
日本
项目类别：
Grant-in-Aid for JSPS Fellows
财政年份：
2023
资助国家：
日本
起止时间：
2023-03-08 至 2025-03-31
项目状态：
未结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22KF0066/
关键词：
Lab-on-a-CD electrical measurements Malaria

项目摘要

We are going on with the development of the lab-on-a-CD hardware in Takei laboratory in Nishi Chiba campus of Chiba University. Takei laboratory in Nishi Chiba campus of Chiba University. At the moment, we have managed to assemble the main components of the lab-on-a-CD hardware and improving the stability of the hardware to a robust form that can be easily transported between Takei laboratory in Nishi Chiba campus of Chiba University to the infection and host defense laboratory in Inohana campus of Chiba University where we shall be doing experiments using cultured malaria parasites. Since malaria is not endemic in Japan, the robustness will also enable the lab-on-a-CD hardware to be easily transported to Kenya where we are doing a collaborative research with Jomo Kenyatta University Of Agriculture and Technology (JKUAT) as well the institute of Primate Research (IPR). We are also doing in-vitro sensor analysis using Normal saline at increasing concentration to determine the functionality of each sensor. We are also using a mixture of chicken blood to represent malaria blood mixed with porcine blood to represent normal human blood to check if the hardware can help to determine the volume fraction of chicken blood in the porcine blood. These initial in-vitro studies will help to identify the major problems in the various components of the hardware such as in the 8- sensor array system or the Arduino or any other part that may cause the inconsistences in the impedance measurement results using the novel lab-on-a-CD hardware in diagnosis of malaria.

我们正在千叶大学西千叶校区武井实验室继续开发光盘实验室硬件。千叶大学西千叶校区武井实验室。目前，我们已经成功组装了 CD 实验室硬件的主要组件，并提高了硬件的稳定性，使其成为一种坚固的形式，可以轻松地在千叶大学西千叶校区武井实验室和千叶大学西千叶校区武井实验室之间运输。千叶大学井之花校区的感染和宿主防御实验室，我们将在那里使用培养的疟疾寄生虫进行实验。由于疟疾在日本并非流行病，因此其坚固性还将使 CD 实验室硬件能够轻松运输到肯尼亚，我们正在肯尼亚与乔莫·肯雅塔农业技术大学 (JKUAT) 以及该研究所进行合作研究灵长类动物研究（IPR）。我们还使用浓度不断增加的生理盐水进行体外传感器分析，以确定每个传感器的功能。我们还使用代表疟疾血液的鸡血与代表正常人类血液的猪血的混合物来检查硬件是否可以帮助确定猪血中鸡血的体积分数。这些初步的体外研究将有助于确定硬件各个组件中的主要问题，例如 8 传感器阵列系统或 Arduino 或任何其他可能导致使用新颖实验室的阻抗测量结果不一致的部分用于诊断疟疾的 CD 硬件。