Development and evaluation of three-stage procedures for modelling exposure patterns in epidemiological studies

流行病学研究中暴露模式建模的三阶段程序的开发和评估

• 批准号: 391977161
• 负责人: Professorin Dr. Iris Pigeot
• 金额: --
• 依托单位: Leibniz-Institut für Präventionsforschung und Epidemiologie - BIPS GmbH
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/391977161?language=en
• 关键词: Development; evaluation; three; stage; procedures

The interaction of various lifestyle-related factors contributes substantially to the development of multifactorial diseases such as diabetes, obesity and cancer. This project aims to develop a novel three-stage procedure (3-SP), and to investigate its properties and practical application, so as to improve the statistical analysis of the role of such factors in the development of diseases within the context of epidemiological studies. The 3-SP is specifically designed to address the growing complexity of available data, as methods traditionally employed in epidemiological studies fall short of this challenge. The growing complexity of the data is due to technical advances of recent years which enabled an increased validity of survey instruments. For instance, web-based 24-hour dietary recalls and wearable accelerometers are now routinely used to assess dietary intake and physical activity over a time period by frequent repeated measurements. To model the relation between exposure and outcome appropriately based on such high-dimensional data with intra-individual variation the 3-SP proceeds in three steps. At the first stage, the usual exposure is derived using error correction models accounting for intra-individual variation. This provides the basis for the second stage, where cluster models are used to assign individuals to exposure patterns which in turn are used at the third stage to model associations between such patterns and the outcome of interest using regression models. This multi-stage combination of different statistical methods gives rise to an error propagation which needs to be taken into account when investigating the properties of the final estimators. Furthermore, it needs to be addressed which method is most appropriate and feasible at each stage.Hence, the project will investigate the theoretical bias and the variance of estimators derived by combining different methods in the 3-SP; moreover, recommendations for the application of the 3-SP will be developed and its practical feasibility examined. To this end, error correction methods such as SIMEX will be considered, theoretical investigations and a simulation study will be conducted. The feasibility of the 3-SP methodology for practical applications will be investigated using data from the recently completed IDEFICS/I.Family studies. These studies provide cohort data on 16,228 European children aged 2 to 9.9 years. Due to the detailed phenotyping of the participating children the data offer a typical applied context for assessing the proposed methodology.

各种生活方式相关因素的相互作用极大地促进了多因素疾病（例如糖尿病，肥胖和癌症）的发展。该项目旨在开发一种新颖的三阶段程序（3-SP），并研究其特性和实际应用，以改善这种因素在流行病学研究背景下此类因素在疾病发展中的作用的统计分析。 3-SP是专门设计的，旨在解决可用数据的日益增长的复杂性，因为流行病学研究中传统上采用的方法没有达到这一挑战。数据的复杂性越来越复杂，这是由于近年来的技术进步，这使调查工具的有效性提高了。例如，基于Web的24小时饮食召回和可穿戴加速度计，现在通常使用经常重复测量来评估一段时间内饮食摄入和体育锻炼。为了基于与个体内部变化的高维数据，适当地对暴露与结果之间的关系建模，3-SP分为三个步骤进行。在第一阶段，通常使用误差校正模型来介绍个人内部变化。这为第二阶段提供了基础，在该阶段中，聚类模型用于将个人分配给曝光模式，而这些模式又在第三阶段将这种模式与使用回归模型之间的相关性建模。不同统计方法的多阶段组合产生了错误传播，在研究最终估计器的属性时，需要考虑到该错误传播。此外，需要解决哪种方法在每个阶段最合适，最可行。因此，该项目将通过结合3-SP中的不同方法来研究理论偏差和估计量的差异；此外，将开发有关应用3-SP的建议及其实际可行性。为此，将考虑诸如SIMEX之类的误差校正方法，理论研究和模拟研究将进行。将使用来自最近完成的IDEFICS/i.FAMILY研究的数据来研究3-SP方法对实际应用的可行性。这些研究提供了有关2至9.9岁的16,228名欧洲儿童的队列数据。由于参与儿童的详细表型，数据提供了一种典型的应用背景，用于评估所提出的方法。

项目成果

SIMEX for correction of dietary exposure effects with Box‐Cox transformed data

SIMEX 通过 BoxâCox 转换数据校正饮食暴露影响

• DOI: 10.1002/bimj.201900066
• 发表时间: 2020
• 期刊: Biometrical Journal
• 影响因子: 1.7
• 作者: Intemann T;Mehlig K;De Henauw S;Siani A;Constantinou T;Moreno LA;Molnár D;Veidebaum T;Pigeot I on behalf of the I.Family consortium
• 通讯作者: Pigeot I on behalf of the I.Family consortium