An investigation of novel therapeutic strategies for platinum-resistant ovarian cancer using cancer organoid originated from disseminating ovarian carcinoma

使用源自播散性卵巢癌的癌症类器官研究铂耐药性卵巢癌的新治疗策略

• 批准号: 19K09747
• 负责人: TSUJI Keita
• 金额: $ 2.83万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K09747/
• 关键词: 卵巣癌; 白金製剤; 治療抵抗性; CHD4; オルガノイド; プラチナ感受性; オルガノイドモデル; プラチナ耐性

项目成果

Functional analysis of ZFHX4 as a novel therapeutic target in ovarian cancer

ZFHX4作为卵巢癌新治疗靶点的功能分析

• 发表时间: 2020
• 作者: Yoshiko Oyama;Shogo Shigeta;Keita Tsuji;Hideki Tokunaga;Muneaki Shimada;Nobuo Yaegashi
• 通讯作者: Nobuo Yaegashi

CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents.

• DOI: 10.1371/journal.pone.0251079
• 发表时间: 2021
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Oyama Y;Shigeta S;Tokunaga H;Tsuji K;Ishibashi M;Shibuya Y;Shimada M;Yasuda J;Yaegashi N
• 通讯作者: Yaegashi N