Novel mechanism of chronic inflammation in progression and destabilization of atherosclerotic plaque

慢性炎症在动脉粥样硬化斑块进展和不稳定中的新机制

• 批准号: 19H03654
• 负责人: SATA Masataka
• 金额: $ 11.23万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19H03654/
• 关键词: 動脈硬化; 慢性炎症; 自然免疫; 脂質異常症; 自己核酸; アポトーシス; STING; Toll様受容体; インスリン抵抗性; 骨髄; 血管; マクロファージ; 生活習慣病; 肥満

项目成果

Sirt7 Deficiency Attenuates Neointimal Formation Following Vascular Injury by Modulating Vascular Smooth Muscle Cell Proliferation

Sirt7 缺陷通过调节血管平滑肌细胞增殖来减弱血管损伤后的新内膜形成

• DOI: 10.1253/circj.cj-20-0936
• 发表时间: 2021
• 影响因子: 3.3
• 作者: 木村 優一

Atherosclerotic Coronary Plaque Is Associated With Adventitial Vasa Vasorum and Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadavers

动脉粥样硬化冠状动脉斑块与新鲜尸体中的外膜血管和邻近心外膜脂肪组织的局部炎症有关

• DOI: 10.1253/circj.cj-19-0914
• 发表时间: 2020
• 影响因子: 3.3
• 作者: Ito Hiroyuki;Wakatsuki Tetsuzo;Yamaguchi Koji;Fukuda Daiju;Kawabata Yutaka;Matsuura Tomomi;Kusunose Kenya;Ise Takayuki;Tobiume Takeshi;Yagi Shusuke;Yamada Hirotsugu;Soeki Takeshi;Tsuruo Yoshihiro;Sata Masataka
• 通讯作者: Sata Masataka

Association of Local Epicardial Adipose Tissue Depots and Left Ventricular Diastolic Performance in Patients With Preserved Left Ventricular Ejection Fraction

左心室射血分数保留的患者局部心外膜脂肪组织库与左心室舒张功能的关系

• DOI: 10.1253/circj.cj-19-0793
• 发表时间: 2020
• 影响因子: 3.3
• 作者: Maimaituxun Gulinu;Yamada Hirotsugu;Fukuda Daiju;Yagi Shusuke;Kusunose Kenya;Hirata Yukina;Nishio Susumu;Soeki Takeshi;Masuzaki Hiroaki;Sata Masataka;Shimabukuro Michio
• 通讯作者: Shimabukuro Michio

Diagnostic Criteria of Flow‐Mediated Vasodilation for Normal Endothelial Function and Nitroglycerin‐Induced Vasodilation for Normal Vascular Smooth Muscle Function of the Brachial Artery

正常内皮功能的血流介导的血管舒张和肱动脉正常血管平滑肌功能的硝酸甘油诱导的血管舒张的诊断标准

• DOI: 10.1161/jaha.119.013915
• 发表时间: 2020
• 影响因子: 5.4
• 作者: Maruhashi Tatsuya;Tomiyama Hirofumi;Takemoto Yasuhiko;Sata Masataka;Node Koichi;Higashi Yukihito
• 通讯作者: Higashi Yukihito

Febuxostat does not delay progression of carotid atherosclerosis in patients with asymptomatic hyperuricemia: A randomized, controlled trial.

非布索坦不会延缓无症状高尿酸血症患者颈动脉粥样硬化的进展：一项随机对照试验。

• DOI: 10.1371/journal.pmed.1003095
• 发表时间: 2020
• 影响因子: 15.8
• 作者: Tanaka A; Taguchi I; Teragawa H; Ishizaka N; Kanzaki Y; Tomiyama H; Sata M; Sezai A; Eguchi K; Kato T; Toyoda S; Ishibashi R; Kario K; Ishizu T; Ueda S; Maemura K; Higashi Y; Yamada H; Ohishi M; Yokote K; Murohara T; Oyama JI; Node K;PRIZE study investig
• 通讯作者: PRIZE study investig