A genome-wide association study in Japanese patients with rheumatoid arthritis in order to identify susceptibility loci for Methotrexate-associated lymphoproliferative disorder.

对日本类风湿性关节炎患者进行的一项全基因组关联研究，旨在确定甲氨蝶呤相关淋巴增殖性疾病的易感位点。

• 批准号: 20H03722
• 负责人: Harigai Masayoshi
• 金额: $ 11.32万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20H03722/
• 关键词: 関節リウマチ; リンパ腫; 遺伝子; メトトレキサート関連リンパ腫; ゲノムワイド関連解析; メトトレキサート関連リンパ増殖性疾患; 関連遺伝子; MTX-LPD; メトトレキサート

项目成果

Association of Polygenic Risk Scores With Radiographic Progression in Patients With Rheumatoid Arthritis

• DOI: 10.1002/art.42051
• 发表时间: 2022-03-24
• 期刊: ARTHRITIS & RHEUMATOLOGY
• 影响因子: 13.3
• 作者: Honda, Suguru;Ikari, Katsunori;Kochi, Yuta
• 通讯作者: Kochi, Yuta

Nationwide clinical and epidemiological study of large-vessel vasculitis in Japan in 2017

• DOI: 10.1093/mr/road019
• 发表时间: 2023-02-04
• 期刊: MODERN RHEUMATOLOGY
• 影响因子: 2.2
• 作者: Konda, Naoko;Sakai, Ryoko;Harigai, Masayoshi
• 通讯作者: Harigai, Masayoshi

Risk of hospitalized infections in older elderly patients with rheumatoid arthritis treated with tocilizumab or other biological/targeted synthetic disease-modifying antirheumatic drugs: Evaluation of data from a Japanese claims database

使用托珠单抗或其他生物/靶向合成缓解病情抗风湿药物治疗的老年类风湿性关节炎患者住院感染的风险：对日本理赔数据库数据的评估

• DOI: 10.1093/mr/road031
• 发表时间: 2023
• 期刊: Modern Rheumatology
• 影响因子: 2.2
• 作者: Harigai Masayoshi;Fujii Takao;Sakai Ryoko;Igarashi Ataru;Shoji Ayako;Yamaguchi Hiroko;Iwasaki Katsuhiko;Makishima Misako;Yoshida Amika;Okada Norihiro;Yamashita Katsuhisa;Kawahito Yutaka
• 通讯作者: Kawahito Yutaka

Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.

• DOI: 10.1038/s41588-022-01213-w
• 发表时间: 2022-11
• 期刊: NATURE GENETICS
• 影响因子: 30.8
• 作者: Ishigaki, Kazuyoshi;Sakaue, Saori;Terao, Chikashi;Luo, Yang;Sonehara, Kyuto;Yamaguchi, Kensuke;Amariuta, Tiffany;Too, Chun Lai;Laufer, Vincent A.;Scott, Ian C.;Viatte, Sebastien;Takahashi, Meiko;Ohmura, Koichiro;Murasawa, Akira;Hashimoto, Motomu;Ito, Hiromu;Hammoudeh, Mohammed;Al Emadi, Samar;Masri, Basel K.;Halabi, Hussein;Badsha, Humeira;Uthman, Imad W.;Wu, Xin;Lin, Li;Li, Ting;Plant, Darren;Barton, Anne;Orozco, Gisela;Verstappen, Suzanne M. M.;Bowes, John;MacGregor, Alexander J.;Honda, Suguru;Koido, Masaru;Tomizuka, Kohei;Kamatani, Yoichiro;Tanaka, Hiroaki;Tanaka, Eiichi;Suzuki, Akari;Maeda, Yuichi;Yamamoto, Kenichi;Miyawaki, Satoru;Xie, Gang;Zhang, Jinyi;Amos, Christopher, I;Keystone, Edward;Wolbink, Gertjan;Van der Horst-Bruinsma, Irene;Cui, Jing;Liao, Katherine P.;Carroll, Robert J.;Lee, Hye-Soon;Bang, So-Young;Siminovitch, Katherine A.;de Vries, Niek;Alfredsson, Lars;Rantapaa-Dahlqvist, Solbritt;Karlson, Elizabeth W.;Bae, Sang-Cheol;Kimberly, Robert P.;Edberg, Jeffrey C.;Mariette, Xavier;Huizinga, Tom;Dieude, Philippe;Schneider, Matthias;Kerick, Martin;Denny, Joshua C.;Matsuda, Koichi;Matsuo, Keitaro;Mimori, Tsuneyo;Matsuda, Fumihiko;Fujio, Keishi;Tanaka, Yoshiya;Kumanogoh, Atsushi;Traylor, Matthew;Lewis, Cathryn M.;Eyre, Stephen;Xu, Huji;Saxena, Richa;Arayssi, Thurayya;Kochi, Yuta;Ikari, Katsunori;Harigai, Masayoshi;Gregersen, Peter K.;Yamamoto, Kazuhiko;Bridges, S. Louis, Jr.;Padyukov, Leonid;Martin, Javier;Klareskog, Lars;Okada, Yukinori;Raychaudhuri, Soumya
• 通讯作者: Raychaudhuri, Soumya

Late-onset rheumatoid arthritis registry study, LORIS study: study protocol and design.

• DOI: 10.1186/s41927-022-00322-7
• 发表时间: 2022-12-26
• 期刊: BMC RHEUMATOLOGY
• 影响因子: 2.2
• 作者: Kojima, Masayo;Kawahito, Yutaka;Sugihara, Takahiko;Kojima, Toshihisa;Harada, Ryozo;Hirata, Shintaro;Hashimoto, Motomu;Hidaka, Toshihiko;Ishikawa, Hajime;Ito, Hiromu;Kishimoto, Mitsumasa;Kaneko, Yuko;Matsui, Kazuo;Matsui, Toshihiro;Matsushita, Isao;Morinobu, Akio;Nishida, Keiichiro;Tanaka, Eiichi;Abe, Asami;Ishitoku, Michinori;Asai, Shuji;Kida, Takashi;Onishi, Akira;Takanashi, Satoshi;Harigai, Masayoshi
• 通讯作者: Harigai, Masayoshi