Establishment of an aging brain environment model as a basis for iPS cell research on neurodegenerative diseases.

建立衰老脑环境模型作为iPS细胞研究神经退行性疾病的基础。

• 批准号: 19K16930
• 负责人: Takahiro Shiga
• 金额: $ 2.75万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K16930/
• 关键词: iPS細胞; パーキンソン病; 老化; アストロサイト; グリア; 神経変性疾患; 疾患モデル

项目成果

In vitro monitoring of HTR2A-positive neurons derived from human-induced pluripotent stem cells

人诱导多能干细胞来源的 HTR2A 阳性神经元的体外监测

• DOI: 10.1038/s41598-021-95041-3
• 发表时间: 2021
• 影响因子: 4.6
• 作者: Nakai Kento;Shiga Takahiro;Yasuhara Rika;Sarkar Avijite Kumer;Abe Yuka;Nakamura Shiro;Hoashi Yurie;Kotani Keisuke;Tatsumoto Shoji;Ishikawa Hiroe;Go Yasuhiro;Inoue Tomio;Mishima Kenji;Akamatsu Wado;Baba Kazuyoshi
• 通讯作者: Baba Kazuyoshi

Generation of two iPSC lines from siblings of a homozygous patient with hearing loss and a heterozygous carrier with normal hearing carrying p.G45E/Y136X mutation in GJB2

从患有听力损失的纯合子患者和携带 GJB2 p.G45E/Y136X 突变的听力正常的杂合子携带者的兄弟姐妹中生成两个 iPSC 系

• DOI: 10.1016/j.scr.2021.102290
• 发表时间: 2021
• 影响因子: 1.2
• 作者: Fukunaga Ichiro;Oe Yoko;Danzaki Keiko;Ohta Sayaka;Chen Cheng;Iizumi Madoka;Shiga Takahiro;Matsuoka Rina;Anzai Takashi;Hibiya;Tajima Shori;Ikeda Katsuhisa;Akamatsu Wado;Kamiya Kazusaku
• 通讯作者: Kamiya Kazusaku

Generation of two iPSC lines from siblings of a homozygous patient with hearing loss and a heterozygous carrier with normal hearing carrying p.G45E/Y136X mutation in GJB2

从患有听力损失的纯合子患者和携带 GJB2 p.G45E/Y136X 突变的听力正常的杂合子携带者的兄弟姐妹中生成两个 iPSC 系

• DOI: 10.1016/j.scr.2021.102290
• 发表时间: 2021
• 影响因子: 1.2
• 作者: Fukunaga Ichiro;Oe Yoko;Danzaki Keiko;Ohta Sayaka;Chen Cheng;Iizumi Madoka;Shiga Takahiro;Matsuoka Rina;Anzai Takashi;Hibiya;Tajima Shori;Ikeda Katsuhisa;Akamatsu Wado;Kamiya Kazusaku
• 通讯作者: Kamiya Kazusaku

Generation of two induced pluripotent stem cell lines from PBMCs of siblings carrying c.235delC mutation in the GJB2 gene associated with sensorineural hearing loss

从携带与感音神经性听力损失相关的 GJB2 基因 c.235delC 突变的兄弟姐妹的 PBMC 中生成两种诱导多能干细胞系

• DOI: 10.1016/j.scr.2020.101910
• 发表时间: 2020
• 影响因子: 1.2
• 作者: Fukunaga Ichiro;Shirai Kyoko;Oe Yoko;Danzaki Keiko;Ohta Sayaka;Shiga Takahiro;Chen Cheng;Ikeda Katsuhisa;Akamatsu Wado;Kawano Atsushi;Kamiya Kazusaku
• 通讯作者: Kamiya Kazusaku

Increased excitability of human iPSC-derived neurons in HTR2A variant-related sleep bruxism

HTR2A 变异相关的睡眠磨牙症中人类 iPSC 衍生神经元的兴奋性增加

• DOI: 10.1016/j.scr.2022.102658
• 发表时间: 2022
• 影响因子: 1.2
• 作者: Sarkar Avijite Kumer;Nakamura Shiro;Nakai Kento;Sato Taro;Shiga Takahiro;Abe Yuka;Hoashi Yurie;Inoue Tomio;Akamatsu Wado;Baba Kazuyoshi
• 通讯作者: Baba Kazuyoshi