Exploring the mechanism of mutation acquisition to induce tumorigenesis using Down syndrome associated leukemia model

利用唐氏综合症相关白血病模型探讨突变获得诱导肿瘤发生的机制

• 批准号: 19K17358
• 负责人: Nishinaka-Arai Yoko
• 金额: $ 2.66万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K17358/
• 关键词: 一過性骨髄異常増殖症; 発がん; 多段階発がん; ダウン症候群; 白血病

项目成果

hPSC model reveals impact of GATA1 mutation on a newly defined subpopulation leading to TAM

hPSC 模型揭示了 GATA1 突变对新定义的导致 TAM 的亚群的影响

• 发表时间: 2019
• 作者: Yoko Nishinaka-Arai;Akira Niwa;Shiori Matsuo;Yasuhiro Kazuki;Yuwna Yakura;Takehiro Hiroma;Tsutomu Toki;Tetsushi Sakuma;Takashi Yamamoto;Etsuro Ito;Mitsuo Oshimura;Tatsutoshi Nakahata;and Megumu K. Saito
• 通讯作者: and Megumu K. Saito

Down syndrome-related transient abnormal myelopoiesis is attributed to a specific erythro-megakaryocytic subpopulation with GATA1 mutation.

• DOI: 10.3324/haematol.2019.242693
• 发表时间: 2021-02-01
• 期刊: Haematologica
• 影响因子: 10.1
• 作者: Nishinaka-Arai Y;Niwa A;Matsuo S;Kazuki Y;Yakura Y;Hiroma T;Toki T;Sakuma T;Yamamoto T;Ito E;Oshimura M;Nakahata T;Saito MK
• 通讯作者: Saito MK

Down syndrome-related transient abnormal myelopoiesis is derived from a newly identified hematopoietic subpopulation

唐氏综合症相关的短暂异常骨髓细胞生成源自新发现的造血亚群

• 发表时间: 2019
• 作者: Yoko Nishinaka-Arai;Akira Niwa;Shiori Matsuo;Yasuhiro Kazuki;Yuwna Yakura;Takehiro Hiroma;Tsutomu Toki;Tetsushi Sakuma;Takashi Yamamoto;Etsuro Ito;Mitsuo Oshimura;Tatsutoshi Nakahata;and Megumu K. Saito
• 通讯作者: and Megumu K. Saito

Pluripotent stem cell model of early hematopoiesis in Down syndrome reveals quantitative effects of short-form GATA1 protein on lineage specification.

• DOI: 10.1371/journal.pone.0247595
• 发表时间: 2021
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Matsuo S;Nishinaka-Arai Y;Kazuki Y;Oshimura M;Nakahata T;Niwa A;Saito MK
• 通讯作者: Saito MK