Elucidation of the mechanism of hematogenous organ-specific metastasis formation focusing on the heterogeneity of angiogenesis mechanism of hematogenous organ-specific metastasis formation

阐明血行器官特异性转移形成机制，重点关注血行器官特异性转移形成的血管生成机制的异质性

• 批准号: 20K17657
• 负责人: NAKAYAMA Hiromichi
• 金额: $ 2.66万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20K17657/
• 关键词: 血管新生; 膵癌; 血行性転移; ADM; M2; マクロファージ; MMP9; IL12A; CD31; M2マクロファージ; sprouting angiogenesis; vasculogenesis; 同種骨髄移植KPCマウス; VEGFR; 微小環境; 転移臓器特異性

项目成果

造血幹細胞由来CAF subsetが腫瘍内heterogeneityを高度化する

造血干细胞衍生的 CAF 亚群增强瘤内异质性

• 发表时间: 2021
• 作者: 岩本千佳;大内田研宙;新川智彦;相良亜希子;奥田翔;小山虹輝;進藤幸治;池永直樹;仲田興平;森山大樹;中村雅史
• 通讯作者: 中村雅史

Human macrophages-derived CAF-like cells lead the invasion of pancreatic cancer

人巨噬细胞衍生的CAF样细胞引领胰腺癌的侵袭

• 发表时间: 2020
• 作者: Iwamoto C; Ohuchida K; Shinkawa T; Otsubo Y; Shindo K; Moriyama T; Nakata K; Ohtsuka T; Nakamura M
• 通讯作者: Nakamura M

Bone marrow-derived macrophages converted into cancer-associated fibroblast-like cells promote pancreatic cancer progression

骨髓源性巨噬细胞转化为癌症相关成纤维细胞样细胞促进胰腺癌进展

• DOI: 10.1016/j.canlet.2021.04.013
• 发表时间: 2021
• 影响因子: 9.7
• 作者: Iwamoto Chika;Ohuchida Kenoki;Shinkawa Tomohiko;Okuda Sho;Otsubo Yoshiki;Okumura Takashi;Sagara Akiko;Koikawa Kazuhiro;Ando Yohei;Shindo Koji;Ikenaga Naoki;Nakata Kohei;Moriyama Taiki;Miyasaka Yoshihiro;Ohtsuka Takao;Eto Masatoshi;Akashi Koichi;Nakamura M
• 通讯作者: Nakamura M

Subtype classification of pancreatic ductal adenocarcinoma based on microenvironmental niche factors dependency and chemotherapy resistance

基于微环境生态位因子依赖和化疗耐药的胰腺导管腺癌亚型分类

• 发表时间: 2020
• 作者: Shinkawa T; Ohuchida K; Iwamoto C; Shindo K; Nakata K; Ohtsuka T; Nakamura M
• 通讯作者: Nakamura M