Development of a patient-personalized synapse proteomics technology for advancing precision diagnosis of mental disorders

开发患者个性化突触蛋白质组学技术以推进精神疾病的精确诊断

• 批准号: 21K07554
• 负责人: TAOUFIQ Zacharie
• 金额: $ 2.5万
• 依托单位: Okinawa Institute of Science and Technology Graduate University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2021
• 资助国家: 日本
• 起止时间: 2021-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21K07554/
• 关键词: Synapse; Deep proteomics; Schizophrenia; Mental disorders; iPS-derived neurons; iPSC-derived neurons; proteomics; psychiatry; diagnosis; biomarkers

In collaboration with the Budapest Research Center for Natural Sciences, I have received analyzed 3 new iPSC samples coming from Caucasian family having a living schizophrenia individual. The synapse proteomics analysis revealed significant impaired expression of some specific lipid metabolic enzymes compared healthy.I have started a collaboration with RIKEN AIP for building AI/Machine learning tools to interpret and analyze synapse proteomics data from our psychiatric patient cohort.

与布达佩斯自然科学研究中心合作，我收到了来自具有精神分裂症患者的高加索家族的3个新的IPSC样本。突触蛋白质组学分析表明，与健康相比，某些特定的脂质代谢酶的表达显着受损。我已经与Riken AIP合作，用于构建AI/机器学习工具，以解释和分析我们的精神病患者同类的突触蛋白质组学数据。

项目成果

‘Molecular anatomy of brain synapses from living psychiatric patients’

“活体精神病患者脑突触的分子解剖学”

• 发表时间: 2022
• 作者: 西村拡起;古宮淳一;Zacharie Taoufiq
• 通讯作者: Zacharie Taoufiq

Molecular anatomy of brain synapses from living psychiatric patients’

活体精神病患者脑突触的分子解剖学

• 发表时间: 2021
• 作者: Hosoda Yutaka;Ohtani Toshiyuki;Hanazawa Hisashi;Tanaka Mami;Kimura Hiroshi;Ohsako Noriaki;Hashimoto Tasuku;Kobori Osamu;Iyo Masaomi;Nakazato Michiko;Zacharie Taoufiq
• 通讯作者: Zacharie Taoufiq

Novel peptide drug for treating Alzheimer’s disease.

治疗阿尔茨海默病的新型肽药物。

• 发表时间: 2022

International Symposium on Artificial Intelligence and Brain Science

人工智能与脑科学国际研讨会

• 发表时间: 2022
• 作者: Noriko Numata;Akiko Nakagawa;Kazuko Yoshioka;Kayoko Isomura;Daisuke Matsuzawa;Rikukage Setsu;Michiko Nakazato & Eiji Shimizu;Zacharie Taoufiq
• 通讯作者: Zacharie Taoufiq

Proteomics-based receptor-ligand matching for optimizing human iPS cell reprogramming

基于蛋白质组学的受体-配体匹配，用于优化人类 iPS 细胞重编程

• 发表时间: 2021