Decarboxylative Arylations in Natural Product Synthesis and Transfer Hydrofunctionalizations Using Cyclohexadienes

天然产物合成中的脱羧芳基化和使用环己二烯的转移氢官能化

• 批准号: 269735328
• 负责人: Professor Dr. Armido Studer
• 金额: --
• 依托单位: Organisch-Chemisches Institut
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/269735328?language=en
• 关键词: Decarboxylative; Arylations; Natural; Product; Synthesis

In the second project period, the Pd-catalyzed decarboxylative gamma-arylation and other methods developed during the first funding period will be applied to the synthesis of various aryltetralinlignanes. Along with natural product synthesis, one part of project is devoted to methods development. Along those lines, it is planned to use functionalized cyclohexadiene derivatives as reagents in Pd- and Ni-catalyzed alkene transfer hydrofunctionalizations. Besides cyclohexadiene derivatives, N-sulfonylated dihydropyridines will be prepared and studied as transfer hydrofunctionalization reagents in transition-metal catalyzed alkene functionalizations. The nature of the metal and the ligand should allow controlling regiochemistry as well as stereoselectivity of such transformations. In addition, the same proaromatic reagents will also be applied to radical-type transfer hydrofunctionalization reactions.

在第二个项目期间，PD催化的脱羧γ-包式和在第一个资金期间开发的其他方法将应用于各种芳基邻氨基丁烯烯烃的合成。与天然产品合成一起，项目的一部分专门用于方法开发。沿着这些线路，计划使用官能化的环己二烯衍生物作为Pd和Ni催化的烯烃转移水力官能化的试剂。除了环己二烯衍生物外，还将在过渡金属催化的烯烃功能化中准备并研究N-磺酰化的二氢吡啶。金属和配体的性质应允许控制这种转化的立体选择性。另外，相同的核试剂也将应用于自由基转移的水功能反应。