Strategy Driven Synthesis of Complex Alkaloids

复杂生物碱的策略驱动合成

• 批准号: 2400232
• 负责人: Thomas Maimone
• 金额: $ 57.5万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2400232&HistoricalAwards=false
• 关键词: Strategy; Driven; Synthesis; Complex; Alkaloids

With the support of the Chemical Synthesis program in the Division of Chemistry, Professor Thomas Maimone of the University of California, Berkeley will study new synthetic strategies for the construction of complex, nitrogen-containing molecules. At the core of this work is the identification of powerfully simplifying transformations that can lead to the production of topologically unique target molecules with high overall efficiency. The targets chosen for this program challenge the current state-of-the-art in complex molecule synthesis. Results of these endeavors are expected to have a positive impact across the societally important field of organic chemical synthesis which is used to produce medicines, agrochemicals, and materials industrially. This work will also serve as intellectually stimulating training for graduate students who will become future scientists in these fields. Moreover, this grant enables wide-reaching science-focused outreach for Bay Area elementary school students as well as local community college transfer students. Professor Maimone is studying complex alkaloid syntheses of members of the caulamidine and myrmicarin families which have important biological properties and unusual molecular architectures. These biosynthetically mysterious molecules have proven challenging as targets for organic chemical synthesis for many years. Professor Maimone’s work will generate new strategies to construct challenging C–C bond linkages and halogenated Sp3 stereocenters and will also put forth new methods for ring formation using small annulation reagents. This work will not only advance the science of synthesis but allow for the construction of ample quantities of rare natural products for further scientific study. As a part of this project, Professor Maimone is also training his coworkers and preparing them for careers in chemical industries and academia.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系化学合成项目的支持下，加州大学伯克利分校的 Thomas Maimone 教授将研究构建复杂含氮分子的新合成策略。这项工作的核心是识别有力地简化了转化，可以产生具有高整体效率的拓扑独特的目标分子，该计划所选择的目标挑战了当前复杂分子合成的最先进技术，预计这些努力将产生积极的结果。影响范围这项工作还将为将成为这些领域未来科学家的研究生提供智力刺激的培训。 Maimone 教授正在研究考拉脒和 myrmicarin 家族成员的复杂生物碱合成，这些生物碱具有重要的生物学特性和不寻常的分子结构。多年来，生物合成的神秘分子作为有机化学合成的目标已被证明具有挑战性，Maimone 教授的工作将产生构建具有挑战性的 C-C 键连接和卤化 Sp3 立构中心的新策略，并将提出使用小型成环试剂形成环的新方法。这项工作不仅将推进合成科学，而且可以构建大量稀有天然产物以供进一步的科学研究。作为该项目的一部分，Maimone 教授还培训他的同事并为他们做好准备。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。