STTR Phase I: A Completely Non-Toxic Blood Bag That Keeps Blood Healthier, Longer

STTR 第一阶段：完全无毒的血袋，使血液保持更健康、更长久

• 批准号: 2335363
• 负责人: KUMAR CHALLA
• 金额: $ 27.5万
• 依托单位: XHEME INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-01-15 至 2024-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2335363&HistoricalAwards=false
• 关键词: STTR; Phase; Completely; Non; Toxic

This Small Business Technology Transfer (STTR) Phase I project is to replace a 50+-year-old technology that uses toxic blood bags with a completely non-toxic blood bag that keeps blood healthier and longer. With the European Union (EU) banning the toxic plasticizer in the current polyvinyl chloride (PVC) blood bags and the disposal of PVC products releasing toxic, chlorine-based chemicals that build up in the water, air, and food chain, this is an urgent need. This technology replaces both PVC and the toxic plasticizer in addition to preventing a short supply of blood. The solution has the potential to save millions of lives yearly while avoiding waste by storing blood longer. The technology can seamlessly integrate into film manufacturing and blood storage infrastructure. The new technology can be expanded into non-toxic dialysis bags, intravenous (IV) bags, medical tubing, and bioprocessing industry applications. The technology's commercial potential in the global blood bag industry is expected to reach about $845 million by 2033. This STTR Phase I project applies interdisciplinary tools, encompassing the chemistry of nanoporous macrostructure materials, polymer engineering, and blood biology, to advance the knowledge required to develop non-toxic composite bags while taking into consideration stringent requirements of physicochemical and mechanical properties for application as a blood bag. The technical challenge is to balance the competing needs of a blood storage container and manufacture using commercial blood bag machinery while ensuring sufficient active surfaces of the composite films without any leaching of the active ingredient during blood storage. The technology development addresses several technical challenges for storing whole blood longer than 28 days while keeping it healthy. Additionally, technical challenges in sealing the composite films while maintaining the required polymer integrity during steam sterilization are addressed. Solutions to the above-mentioned challenges are anticipated to achieve the primary goal of the Phase I project, which is to demonstrate that the non-toxic composite blood bags extend the shelf life of human whole blood by protecting against cold storage-induced oxidative injury and spontaneous hemolysis of red blood cells.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小型企业技术转让 (STTR) 第一阶段项目旨在用完全无毒的血袋取代 50 多年使用有毒血袋的技术，使血液保持更健康和更​​长久。随着欧盟 (EU) 禁止当前聚氯乙烯 (PVC) 血袋中使用有毒增塑剂，并在处理 PVC 产品时释放有毒氯基化学物质，这些化学物质会在水、空气和食物链中积聚，急需。该技术除了可以防止血液供应短缺之外，还可以替代 PVC 和有毒增塑剂。该解决方案有可能每年挽救数百万人的生命，同时通过更长时间地储存血液来避免浪费。该技术可以无缝集成到薄膜制造和血液储存基础设施中。该新技术可扩展到无毒透析袋、静脉注射 (IV) 袋、医用管材和生物加工行业应用。到 2033 年，该技术在全球血袋行业的商业潜力预计将达到约 8.45 亿美元。该 STTR 第一阶段项目应用跨学科工具，包括纳米多孔宏观结构材料的化学、聚合物工程和血液生物学，以推进所需的知识开发无毒复合袋，同时考虑血袋应用的物理化学和机械性能的严格要求。技术挑战是平衡血液储存容器和使用商用血袋机械制造的竞争需求，同时确保复合膜有足够的活性表面，而在血液储存期间不会有任何活性成分的浸出。该技术的开发解决了在保持全血健康的同时储存超过 28 天的全血的多项技术挑战。此外，还解决了在蒸汽灭菌过程中密封复合薄膜同时保持所需聚合物完整性的技术挑战。针对上述挑战的解决方案预计将实现一期项目的主要目标，即证明无毒复合血袋可通过防止冷藏引起的氧化损伤和延长人全血的保质期。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。