Collaborative Research: Developmental origins of emotional and epigenetic resilience among children

合作研究：儿童情绪和表观遗传复原力的发展起源

• 批准号: 2316775
• 负责人: Kimberly D'Anna-Hernandez
• 金额: $ 10.33万
• 依托单位: Marquette University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2316775&HistoricalAwards=false
• 关键词: Collaborative; Research; Developmental; origins; emotional

This project aims to understand disparities in emotional resilience and mental health among mothers and their children who face a high burden of psychological, social, and cultural stress. The research employs biocultural and developmental frameworks to advance fundamental knowledge about how various stress and resilience factors in mothers can shape the stress biology profile of their children, through study of hormonal and molecular changes measured in children’s saliva. The results of the project can contribute to efforts to improve prevention and interventions to reduce disparities in psychological well-being. The project broadens participation of under-represented groups in STEM through mentoring and training of graduate and undergraduate students and community members. Results are shared in both academic and community outlets, supporting public science education and engagement.This study explores various biological pathways through which maternal sociocultural and emotional protective factors and stressors can alter the developing stress biology of a child. The project leverages existing data from a previously NSF-funded birth cohort of children to examine stress and resilience factors in relation to cortisol reactivity to stress tasks and changes in DNA methylation at stress-related genes at two points in childhood (6 months and 3-5 years). Results address the relative importance of early prenatal versus later postnatal exposures, the earliest timing at which stress biology may first be altered in humans, and whether altered stress reactivity signifies a trade-off that ultimately places children at higher risk for emotional or behavioral problems or impaired cognition.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目旨在了解面临心理、社会和文化压力重担的母亲及其子女在情绪恢复力和心理健康方面的差异。该研究采用生物文化和发展框架来增进有关各种压力和恢复力因素如何影响的基础知识。母亲可以通过研究儿童唾液中的荷尔蒙和分子变化来塑造孩子的压力生物学特征。该项目的结果有助于改善预防和干预措施，以减少心理健康方面的差异。该项目扩大了参与范围。的通过对研究生、本科生和社区成员的指导和培训，研究结果在学术和社区渠道中共享，支持公共科学教育和参与。这项研究探索了母亲社会文化和情感保护因素的各种生物学途径。该项目利用先前由 NSF 资助的儿童出生队列的现有数据来检查与皮质醇对压力任务的反应以及与压力相关的 DNA 甲基化变化相关的压力和弹性因素。基因在二研究结果探讨了早期产前暴露与产后暴露的相对重要性、人类应激生物学首次改变的最早时间，以及应激反应是否意味着一种权衡。最终使儿童面临更高的情绪或行为问题或认知受损的风险。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。