RUI: Fetal programming of early brain development and emotional regulation in infants: The role of sociocultural stressors

RUI:婴儿早期大脑发育和情绪调节的胎儿编程:社会文化压力源的作用

基本信息

项目摘要

This project will investigate whether and to what extent prenatal exposure to sociocultural stressors influences early brain development and associated emotional regulation in infants. Impairments in emotional regulation that may be shaped by prenatal experiences are of particular concern because emotional regulation is important for cognitive ability and academic success later in life. Specifically, this project will enhance basic understanding of the role of sociocultural stressors on infant emotional regulation by studying multiple factors, including infants' emotional, physiological, and attentional states, as well as mothers' self-reports. Findings will highlight perinatal factors that affect development and will uncover potential patterns among infant measurements that may uniquely characterize early risk for poor emotional regulation. This project will extend current theories of prenatal stress and infant development and provide multiple research opportunities for students, broadening participation of diverse groups in science. Moreover, this work will integrate teaching and research, a high-impact practice shown to improve learning outcomes and increase graduation rates in students. The project will ascertain if attention-related brain development underlies the effects of prenatal stress exposure on emotional regulation in at-risk infants. First, to determine if such brain development is related to prenatal stress exposure, mothers will report on levels of sociocultural stress experienced during their pregnancy. At birth, electrophysiological activity in the infants' brains will be assessed to evaluate brain development and attention functioning. At 6 months of age, a social stressor will be used to determine if the relationship between prenatal stress exposure and infant emotional dysregulation is strengthened by early neurodevelopment of attention functioning. While experiencing the stressor--an interaction in which a mother looks at her infant while maintaining a nonmoving, neutral facial expression--infants' heart rate variability, cortisol responses, and negative vocalizations will be measured for subsequent analysis. By using a variety of measures, inferences can be made about the potential dyssynchrony between behavioral and physiological response systems, which may itself indicate emotional dysregulation in young children. This work will utilize a multidisciplinary, multi-method approach that integrates social, behavioral, and biological levels of analysis to understand processes related to development and learning in children.
该项目将调查产前暴露于社会文化压力源是否以及在多大程度上影响婴儿的早期大脑发育和相关的情绪调节。产前经历可能造成的情绪调节障碍尤其值得关注,因为情绪调节对于以后的认知能力和学业成功非常重要。具体来说,该项目将通过研究多种因素,包括婴儿的情绪、生理和注意力状态以及母亲的自我报告,增强对社会文化压力源对婴儿情绪调节作用的基本了解。研究结果将强调影响发育的围产期因素,并将揭示婴儿测量中的潜在模式,这些模式可能独特地表征情绪调节不良的早期风险。该项目将扩展当前的产前应激和婴儿发育理论,并为学生提供多种研究机会,扩大不同群体对科学的参与。此外,这项工作将整合教学和研究,这是一种具有高影响力的实践,可以改善学习成果并提高学生的毕业率。该项目将确定与注意力相关的大脑发育是否是产前压力暴露对高危婴儿情绪调节影响的基础。首先,为了确定这种大脑发育是否与产前压力暴露有关,母亲将报告其怀孕期间经历的社会文化压力水平。出生时,将评估婴儿大脑的电生理活动,以评估大脑发育和注意力功能。 6 个月大时,将使用社会压力源来确定产前压力暴露与婴儿情绪失调之间的关系是否因注意力功能的早期神经发育而得到加强。在经历压力源(母亲看着婴儿同时保持静止、中性面部表情的互动)时,将测量婴儿的心率变异性、皮质醇反应和负面发声以进行后续分析。通过使用各种措施,可以推断出行为和生理反应系统之间潜在的不同步,这本身可能表明幼儿的情绪失调。这项工作将利用多学科、多方法的方法,整合社会、行为和生物学层面的分析,以了解与儿童发展和学习相关的过程。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Sociocultural stressors across the perinatal period and risk for postpartum depressive symptoms in women of Mexican descent.
墨西哥裔女性围产期的社会文化压力和产后抑郁症状的风险。
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Kimberly D'Anna-Hernandez其他文献

Kimberly D'Anna-Hernandez的其他文献

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{{ truncateString('Kimberly D'Anna-Hernandez', 18)}}的其他基金

Collaborative Research: Developmental origins of emotional and epigenetic resilience among children
合作研究:儿童情绪和表观遗传复原力的发展起源
  • 批准号:
    2316775
  • 财政年份:
    2023
  • 资助金额:
    $ 43.72万
  • 项目类别:
    Standard Grant

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