CAREER: Leveraging flow modulation to transform volatile organic compound measurement

职业：利用流量调制来改变挥发性有机化合物的测量

• 批准号: 2346598
• 负责人: Katelynn Perrault Uptmor
• 金额: $ 63.37万
• 依托单位: College of William and Mary
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2346598&HistoricalAwards=false
• 关键词: CAREER; Leveraging; flow; modulation; transform

This project is jointly funded by the Division of Chemistry in the Directorate for Mathematical and Physical Sciences and the Established Program to Stimulate Competitive Research (EPSCoR). The principal investigator is Katelynn Perrault of Chaminade University of Honolulu. She is developing analytical approaches for measuring volatile organic compounds (VOCs), a class of chemicals most commonly associated with odor analysis. A comprehensive technique that permits two independent methods of separation is used to analyze mixtures of volatiles. In addition, statistical procedures are defined to verify the accurate selection of marker compounds given various levels of sample complexity. These approaches may improve future studies on VOCs in forensic science, defense, and other natural science applications. Through the integration of this research with teaching practices and community outreach, Dr. Perrault contributes to the redressing of educational and career access disparities for Native Hawaiian and Pacific Islanders (NHPIs) and other underserved minorities.The project focuses on leveraging a reverse fill/flush (RFF) flow modulator with comprehensive two-dimensional gas chromatography - mass spectrometry (GCxGC-MS) as a tool for improving VOC characterization from complex samples. Chemical measurement of complex VOC matrices is analytically challenging because they are comprised of numerous compounds from different chemical classes, are highly varied in concentration, and have low matrix specificity. The specific aims of this study include the development of procedures for VOC method translation from a GC-MS instrument to a GCxGC-MS instrument using modulation retrofitting. The research team also investigates GCxGC-MS chemometric feature selections on a reference VOC collection with simulated challenges and demonstrates the developed approach on real samples exhibiting high inter-sample VOC variation. Finally, the team conducts the first interdisciplinary study on interpretation of multidimensional chromatographic output by non-specialists to improve communication of data to broader audiences and stakeholders. This program provides a strong analytical basis for the chemical measurement of VOC profiles using GCxGC-MS with RFF to be used in chemical applications. The educational objective of this work is to implement professional development programs that promote career readiness and growth opportunities for students entering the Science, Technology, Engineering, and Mathematics (STEM) workforce. These programs include undergraduate research experiences, course-based research experiences, communication-based curriculum development in quantitative subjects, implementation of active learning strategies, and interactive community events to promote student service learning while increasing engagement of Native Hawaiians and Pacific Islanders in chemistry.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目由数学和物理科学局的化学司以及刺激竞争性研究的既定计划（EPSCOR）共同资助。首席研究人员是檀香山夏捷大学的凯特琳·佩罗（Katelynn Perrault）。她正在开发用于测量挥发性有机化合物（VOC）的分析方法，这是一种与气味分析相关的一类化学物质。一种允许两种独立分离方法的综合技术用于分析挥发物的混合物。此外，定义了统计程序，以验证给定不同级别的样品复杂性的准确选择标记化合物。这些方法可以改善对法医学，国防和其他自然科学应用中VOC的未来研究。通过将这项研究与教学实践和社区宣传的整合在一起，佩罗特博士为夏威夷原住民和太平洋岛民（NHPIS）（NHPIS）（NHPIS）以及其他服务不足的少数群体的教育和职业访问权限纠正做出了贡献。来自复杂样品的表征。复杂VOC矩阵的化学测量在分析上具有挑战性，因为它们由来自不同化学类别的多种化合物组成，浓度高度变化，并且具有较低的矩阵特异性。这项研究的具体目的包括使用调制改造的GC-MS仪器转换为GCXGC-MS仪器的开发。 研究小组还研究了带有模拟挑战的参考VOC收集中的GCXGC-MS化学计量特征选择，并在具有较高样本间VOC变化的真实样品上展示了开发的方法。 最后，该团队对非专业人士对多维色谱输出的解释进行了第一项跨学科研究，以改善数据与更广泛的受众和利益相关者的沟通。该程序为使用带有RFF的GCXGC-MS对VOC谱的化学测量提供了强大的分析基础，用于化学应用。这项工作的教育目标是实施专业发展计划，以促进进入科学，技术，工程和数学（STEM）劳动力的学生的职业准备和成长机会。这些计划包括本科研究经验，基于课程的研究经验，基于沟通的定量学科课程开发，积极学习策略的实施以及互动社区活动，以促进学生服务学习，同时增加夏威夷原住民和太平洋岛民的化学方面的参与。该奖项反映了NSF的法定任务，并通过评估商标来反映出支持者的支持者，该奖项是通过评估范围来进行的，并构成了基础的范围。