SBIR Phase II: An Integrated Biomedical Platform and Custom Algorithm to Optimize Feeding Protocols for Preterm Infants

SBIR 第二阶段：用于优化早产儿喂养方案的综合生物医学平台和定制算法

• 批准号: 2335207
• 负责人: Caryn Bradley
• 金额: $ 94.38万
• 依托单位: NEOCARE INNOVATIONS, INC.
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-03-15 至 2026-02-28
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2335207&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Integrated; Biomedical

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project addresses the economic burdens of healthcare for preterm infants in Neonatal Intensive Care Units (NICUs) across the US by lowering expenses through cost effective technology. On average 400,000 preterm infants are born in the US each year and 49% experience difficulty feeding after discharge. Preterm infants who cannot successfully feed are at increased risk of hospital readmission resulting in significant financial and emotional burdens for their families. In the US the average length of stay for an infant born less than 32 weeks gestation is 13.2 days. The current practice is for babies to remain longer in the NICU at an average cost of $7,000 per day and a national cost of more than $26 billion a year. An estimated 2-day reduction in length of stay with this biomedical device will lower the financial cost of overall neonatal healthcare expenditure by $8.9 billion annually and will reduce the need for future medical interventions because infants are discharged with a stronger early-stage health baseline. Once this product is commonly used in US hospitals, it can be distributed globally to meet demand and benefit infants worldwide.This Small Business Innovation Research (SBIR) Phase II project can save hospitals thousands of dollars while delivering better care and positive patient outcomes. For infants admitted to the NICU, successful oral feeding is a prerequisite for discharge home, but preterm infants often struggle with oral feeding skills largely due to problems coordinating swallowing with breathing. Achieving safe and efficient oral feeding in preterm infants is challenging because of these neurodevelopmental immaturities. Feeding progress is therefore limited by difficulties in maintaining cardiorespiratory stability. This biomedical platform and clinical algorithm interface use big data based on breathing patterns to quantify the synchronization of breathing and swallowing. A precise method of measuring infant breathing patterns during feeding gives clinicians a diagnostic tool to better inform decisions related to feeding advancement. This device provides objective metrics of feeding success and discharge readiness and may result in decreased readmissions for failure to thrive, substantially reducing healthcare utilizations and post-discharge expenditures. Creating technology that helps infants feed better so they can go home sooner promotes improved parent-infant interactions and optimizes infant development.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）II期项目的更广泛的影响/商业潜力通过通过成本效益技术降低费用来解决美国新生儿重症监护病房（NICUS）的早产儿的经济负担。每年在美国，平均有40万名早产儿出生于美国，出院后有49％的婴儿喂养困难。无法成功喂养的早产婴儿会增加医院再入院的风险，从而给家人带来巨大的财务和情感负担。在美国，婴儿妊娠不到32周的婴儿的平均住院时间为13.2天。目前的做法是，婴儿在NICU中的平均成本为每天7,000美元，全国成本超过260亿美元。估计使用这种生物医学设备的住院时间估计缩短了2天，将每年将整体新生儿医疗保健支出的财务成本降低89亿美元，并将减少对未来医疗干预措施的需求，因为婴儿以更强大的早期健康基线出院。一旦该产品通常在美国医院使用，它就可以在全球范围内分发以满足全球需求并受益于婴儿。这项小型企业创新研究（SBIR）II期项目可以为医院节省数千美元，同时提供更好的护理和积极的患者成果。对于接受NICU的婴儿而言，成功的口服喂养是出院的先决条件，但是早产儿经常因口服喂养技能而苦苦挣扎，这在很大程度上是由于与呼吸协调吞咽的问题。由于这些神经发育的不成熟，在早产儿中实现安全有效的口服喂养是具有挑战性的。因此，进食进展受到维持心肺稳定性的困难的限制。这种生物医学平台和临床算法接口使用基于呼吸模式的大数据来量化呼吸和吞咽的同步。喂养过程中测量婴儿呼吸模式的一种精确方法为临床医生提供了一种诊断工具，可以更好地告知与进食相关的决策。 该设备提供了喂养成功和排放准备就绪的客观指标，并可能导致重新入院率下降，从而大大降低了医疗保健利用和入院后支出。创建帮助婴儿更好地喂养的技术，以便他们可以更快地促进改善父母的互动并优化婴儿的发展。该奖项反映了NSF的法定任务，并且使用基金会的知识分子优点和更广泛的影响审查标准，认为值得通过评估值得支持。