LEAP-HI: Towards a Paradigm of Thrombosis-Free Blood-contacting Devices

LEAP-HI：迈向无血栓血液接触装置的典范

• 批准号: 2245427
• 负责人: Arun Kumar Kota
• 金额: $ 50万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2245427&HistoricalAwards=false
• 关键词: LEAP; HI; Towards; Paradigm; Thrombosis

Every year, treatment of cardiovascular diseases requires thousands of heart assists, hundreds of thousands of heart valves, millions of coronary stents, tens of millions of hemodialyzers, and hundreds of millions of catheters. In all these medical devices, the main cause of morbidity and mortality is blood-clotting, which results in billions of dollars in medical costs and lost productivity. This Leading Engineering for America's Prosperity, Health, and Infrastructure (LEAP-HI) award supports fundamental research to help reduce blood-clotting in medical devices. The research will use promising flexible materials and clotting-resistant coatings to address blood-clotting at the molecular-scale, micro-scale and the device-scale. To accomplish this, the research will be conducted by a multidisciplinary team including experts in chemistry, chemical engineering, mechanical engineering, materials science and biomedical engineering. The results of the research have the potential to save millions of lives and billions of dollars each year, thereby directly contributing to America’s health and prosperity. Furthermore, these efforts will encourage STEM participation of underrepresented minorities and positively impact engineering education.Thrombosis in blood-contacting devices is primarily due to poor blood-material interactions in quasi-static conditions, and flow stagnation and supraphysiological shear stresses in dynamic conditions. This research hypothesizes that a combination of tailored hydration layers and flexible materials can lead to thrombosis-free blood-contacting devices. A multidisciplinary team will test this hypothesis through molecular dynamics simulations to understand the role of hydration layers, interfacial spectroscopy to experimentally characterize the hydration layers, fabrication of novel anti-thrombotic coatings based on the molecular dynamics simulations and interfacial spectroscopy, micro-scale evaluation of the blood-material interactions, and device-scale combination of the novel anti-thrombotic coatings and flexible materials.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

每年，治疗心血管疾病需要数千台心脏辅助设备、数十万个心脏瓣膜、数百万个冠状动脉支架、数千万个血液透析器和数亿个导管，在所有这些医疗设备中，这是导致发病和死亡的主要原因。死亡在于血液凝固，这会导致数十亿美元的医疗费用和生产力损失。这项美国繁荣、健康和基础设施领先工程 (LEAP-HI) 奖项支持基础研究，以帮助减少死亡率。该研究将使用有前途的柔性材料和抗凝血涂层来解决分子尺度、微观尺度和设备尺度的血液凝固问题。由化学、化学工程、机械工程、材料科学和生物医学工程专家组成的多学科团队，研究成果每年有可能挽救数百万人的生命和数十亿美元，从而直接为美国的健康和繁荣做出贡献。这些努力将鼓励 STEM 参与血液接触装置中的血栓形成主要是由于准静态条件下血液与材料的相互作用不良以及动态条件下的血流停滞和超生理剪切应力造成的。多学科团队将通过分子动力学模拟来测试这一假设，以了解水化层和界面光谱的作用。实验表征水化层、基于分子动力学模拟和界面光谱的新型抗血栓涂层的制造、血液-材料相互作用的微观评估以及新型抗血栓涂层和柔性材料的设备规模组合该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。