I-Corps: Solid phase matrix for the formulation of pest control agrochemicals

I-Corps：用于配制害虫防治农用化学品的固相基质

• 批准号: 2321053
• 负责人: Charles Opperman
• 金额: $ 5万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2321053&HistoricalAwards=false
• 关键词: Corps; Solid; phase; matrix; formulation

The broader impact/commercial potential of this I-Corps project is the development of technology for management of plant parasitic nematodes (PPN). Using the proposed technology, nematicide may be applied at 1/100th or less its current commercial rate and provide significant reduction in nematode populations and a dramatic increase in crop yield. In addition, it may be possible to deliver other crop production moieties in concert with nematicide, including fertilizer, biologicals, insecticides or fungicides. PPN infection of cash crops causes an excess of $125 billion in worldwide crop damage annually, and PPNs are regarded as the most damaging biotic crop stressor where there is no viable management option, straining global food security. PPN impact every crop plant in every agricultural setting and industry including smallholder and organic farming, forestry, field and truck crops, ornamentals, and turf. For some crops, such as soybean, nematodes are recognized as the major pest. For other crops, nematodes contribute significantly to a net reduction in yield. Achieving safe and effective nematode control is a key part of the movement toward environmentally sustainable agriculture.This I-Corps project is based on the development of a platform enabling a field deployable paper-like seed treatment (nematicide-treated banana paper) to combat plant parasitic nematodes (PPN). Reducing PPN infection of crops will increase crop yield and quality and reduce soil populations of nematodes. The proposed technology combines the ancient art of papermaking with expertise in nematology and fibrous materials, enabling targeted delivery of beneficial small molecules during crop establishment. Incorporation of active ingredients into a lignocellulose matrix, such as banana paper, allows for effective distribution of crop protection agents without interfering with farming practices. The shelf-stable lightweight material may be applied at planting. The prototype under development is an “active” paper sheet with perforated sections to simply wrap and protect the seed (piece). The localization of the active ingredient, either adsorbed directly or embedded in the paper, specifically targets PPN versus beneficial organisms. Nematodes are primarily a seedling disease, so root protection early is critical to the successful establishment of the crop. Early season control translates into reduced post-harvest losses for root and tuber crops as well. Results from multi-year on-farm trials indicate that the proposed technology protects tuber crops from significant infections that lead to both in-season and post-harvest losses.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该 I-Corps 项目更广泛的影响/商业潜力是开发植物寄生线虫 (PPN) 管理技术，使用拟议的技术，杀线虫剂的施用量可以是目前商业用量的 1/100 或更少，并显着减少杀线虫剂的用量。此外，还可以与杀线虫剂一起使用其他作物生产部分，包括肥料、生物制剂、杀虫剂或杀菌剂。经济作物的 PPN 感染每年在全球范围内造成超过 1,250 亿美元的农作物损失，并且 PPN 被认为是在没有可行的管理方案的情况下最具破坏性的生物作物应激源，对全球粮食安全造成影响。对于一些作物，如大豆，线虫被认为是主要害虫。实现安全有效的线虫控制是实现环境可持续农业的关键部分。该 I-Corps 项目基于开发一个平台，可实现可现场部署的纸质种子处理（经过杀线虫剂处理）香蕉纸）来对抗植物寄生线虫（PPN），减少作物的 PPN 感染将提高作物产量和质量，并减少土壤线虫数量。该技术将古老的造纸技术与专业知识相结合。线虫学和纤维材料，能够在作物生长过程中将活性成分掺入木质纤维素基质（例如香蕉纸）中，从而有效地分布作物保护剂，而不会干扰农业实践。正在开发的原型是一种带有穿孔部分的“活性”纸片，用于简单地包裹和保护种子（片）。活性成分的定位，无论是直接吸附还是嵌入纸中，都是专门针对的。 PPN 与有益生物相比，线虫主要是一种幼苗病害，因此早期的根部保护对于作物的成功生长至关重要，这也可以减少根茎作物和块茎作物的收获后损失。 -农场试验表明，拟议的技术可以保护块茎作物免受导致季节内和收获后损失的重大感染。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响进行评估，被认为值得支持审查标准。