Equipment: MRI: Track 2 Acquisition of a Tundra Cryo-electron microscope

设备： MRI：Track 2 采购 Tundra 冷冻电子显微镜

• 批准号: 2319804
• 负责人: Avital Rodal
• 金额: $ 176.73万
• 依托单位: Brandeis University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2319804&HistoricalAwards=false
• 关键词: Equipment; MRI; Track; Acquisition; Tundra

An award is made to Brandeis University to acquire a Thermo-Fisher Tundra cryo-electron microscope. This microscope will enable visualization and analysis of complex structures at the macromolecular level, and will bring together researchers from diverse fields, ranging from materials science and chemistry to cell, molecular, and structural biology, thus fostering interdisciplinary collaboration. It will be available to researchers at Brandeis and in the local region. The microscope will also have a significant impact on education, training, and outreach. It will help train the next generation of scientists, including those from underrepresented groups, through hand-on courses and workshops for undergraduates, graduate students, and postdoctoral scholars. In addition, outreach programs for high school students will increase scientific knowledge and understanding among the public. The research projects enabled by the Tundra cryo-electron microscope span different scientific fields including the study of biomaterials, cells, and biological structures. For example, several groups of researchers will use cryo-electron microscopy to understand how molecules self-assemble into larger structures, as well as how those same design principles could be used to create new synthetic nanomaterials. Other groups will use the instrument to investigate the shapes and functions of cell membranes and proteins. The Tundra microscope will be essential for capturing detailed images and determining the structures of these molecules. Overall, the microscope will advance knowledge of how biological molecules are structured and how they function, which has important implications for understanding of how life works, and for taking inspiration from biology to create the next generation of materials for human use.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

向布兰代斯大学颁发了奖励，以获取热钓鱼苔原冷冻电子显微镜。该显微镜将对大分子水平的复杂结构进行可视化和分析，并将从材料科学和化学到细胞，分子和结构生物学的各种领域的研究人员聚集在一起，从而促进跨学科的协作。 Brandeis和当地的研究人员将使用它。显微镜还将对教育，培训和外展产生重大影响。它将通过为本科生，研究生和博士后学者的手工课程和讲习班来帮助培训下一代科学家，包括来自代表性不足的团体的科学家。此外，高中生的外展计划将增加公众的科学知识和理解。该研究项目由苔原冷冻电子显微镜涵盖不同的科学领域，包括研究生物材料，细胞和生物结构。例如，几个研究人员将使用冷冻电子显微镜来了解分子如何自组装成较大的结构，以及如何使用这些相同的设计原理来创建新的合成纳米材料。其他组将使用该仪器研究细胞膜和蛋白质的形状和功能。苔原显微镜对于捕获详细的图像和确定这些分子的结构至关重要。总体而言，显微镜将促进了解生物分子的结构以及它们的功能的知识，这对了解生活的运作方式具有重要意义，并从生物学中汲取灵感来创建下一代人使用的材料。该奖项反映了NSF的法定任务，并通过使用该基金会的知识分子优点和广泛的影响来评估NSF的法定任务。