Conference: A workshop to understand the current needs for advancing living sentinel research

会议：了解当前推进活体哨点研究需求的研讨会

• 批准号: 2317614
• 负责人: Jonathan Silberg
• 金额: $ 7.61万
• 依托单位: William Marsh Rice University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2317614&HistoricalAwards=false
• 关键词: Conference; workshop; understand; current; needs

The current global pandemic and the risk of future outbreak events has provided a strong motivation to rethink how we monitor and respond to emergent threats. A potential solution is to create sentinel living systems that detect, recognize, actuate, and mitigate emergent biological threats. To create strong stakeholder engagement and define a vision for sentinel systems, a series of activities will be organized that lead to the development of a research roadmap. This roadmap will frame the foundational challenges in detecting and recognizing health and environmental threats in real time and building devices from living and non-living parts that mitigate those threats using synthetic biology. By bringing together researchers from diverse backgrounds and disciplines, including biology, engineering, and materials, this workshop will draw from broad perspectives and expertise ensuring a robust and rigorous discussion that supports the development of a roadmap that advances in the field. The goal of the proposed workshop is to bring together leading scholars in synthetic biology, materials science, and electrical engineering to discuss the foundational knowledge that is required to create smart technologies that detect, recognize, actuate, and mitigate emergent biological threats. Specifically, it will accomplish four objectives. First, prior to the workshop, diverse stakeholders will be engaged using a virtual mechanism to introduce the workshop goals and ask participants to share ideas in response to a set of defined questions. This information will be used to refine the agenda and materials for the workshop to ensure that it stimulates robust stakeholder discussions. Second, focused stakeholder engagement will be accomplished using an in-person workshop. This will involve defining a frame for discussions and a series of breakout sessions where smaller groups of participants discuss and provide feedback on specific topic points. Third, to broaden the in-person workshop participation, virtual breakout sessions will be used to allow remote participants to contribute in real time. These groups will contain stakeholders from different disciplines to bring together different perspectives. Finally, using the digital notes developed through the meeting, participants will be asked to develop a roadmap document in an article form that contains the outcome of recommendations, which will be disseminated to the broader community through a publication.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

当前的全球大流行和未来爆发事件的风险为我们重新思考如何监测和应对紧急威胁提供了强大的动力。一个潜在的解决方案是创建哨兵生命系统来检测、识别、驱动和减轻紧急生物威胁。为了建立强有力的利益相关者参与并定义哨兵系统的愿景，将组织一系列活动来制定研究路线图。该路线图将提出实时检测和识别健康和环境威胁以及利用合成生物学减轻这些威胁的生物和非生物部件构建设备的基本挑战。通过汇集来自生物学、工程学和材料等不同背景和学科的研究人员，本次研讨会将从广泛的视角和专业知识中汲取灵感，确保进行强有力和严格的讨论，以支持制定该领域进步的路线图。拟议研讨会的目标是聚集合成生物学、材料科学和电气工程领域的顶尖学者，讨论创建检测、识别、驱动和减轻新兴生物威胁的智能技术所需的基础知识。具体来说，它将实现四个目标。首先，在研讨会之前，不同的利益相关者将使用虚拟机制参与进来，介绍研讨会的目标，并要求参与者分享想法以回答一组明确的问题。这些信息将用于完善研讨会的议程和材料，以确保激发利益相关者的热烈讨论。其次，将通过现场研讨会来实现利益相关者的集中参与。这将涉及定义讨论框架和一系列分组会议，其中较小的参与者小组讨论特定主题并提供反馈。第三，为了扩大现场研讨会的参与范围，将使用虚拟分组会议，让远程参与者实时做出贡献。这些小组将包含来自不同学科的利益相关者，以汇集不同的观点。最后，参与者将被要求以文章形式制定路线图文件，其中包含建议的结果，并通过出版物向更广泛的社区传播。该奖项反映了 NSF 的法定使命和通过使用基金会的智力优点和更广泛的影响审查标准进行评估，该项目被认为值得支持。