I-Corps: Volumetric Light-Assisted Manufacturing of Dental Implants and Tissue Scaffolds

I-Corps：牙种植体和组织支架的体积光辅助制造

• 批准号: 2234496
• 负责人: Amir Miri
• 金额: $ 5万
• 依托单位: New Jersey Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2023-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2234496&HistoricalAwards=false
• 关键词: Corps; Volumetric; Light; Assisted; Manufacturing

The broader impact/commercial potential of this I-Corps project is the development of a biomanufacturing tool for dental products. To date, most dental implants have been made by selective application of a single starting material by making a specific mold for each case. The main limitations of such approaches are low fabrication speeds, significant labor costs, and lack of stability in materials that are produced. It is crucial to achieve a high fabricate rate and stable constructs without limiting the desired function of the implant or tissue scaffold. An ideal dental implant fabrication method should make molds within minutes. Modern 3D printing techniques and proper material selection enable this technology to rebuild portions of lost tissue.This I-Corps project is based on the development of a customizable, light-assisted, 3D printing platform that allows for quick fabrication of polymer-based inks and hydrogels. The technology will be used to fabricate stable and functional (dental) implants. Such polymeric inks are based on photoresponsive molecules in the material. This technology will use ultraviolet (UV) crosslinking of methacrylate groups in conventional hydrogels or polymer precursors for long-term stability of the selected implant. Advantages of this technology include: a modular chamber for multi-component biomaterials; very rapid fabrication of implants, scaffolds, and surgical tools; a significant level of control creation, and a low-cost product.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该 I-Corps 项目更广泛的影响/商业潜力是开发牙科产品的生物制造工具。迄今为止，大多数牙种植体都是通过为每种情况制作特定的模具来选择性地应用单一原材料来制造的。这种方法的主要局限性是制造速度低、劳动力成本高以及所生产的材料缺乏稳定性。在不限制植入物或组织支架所需功能的情况下实现高制造率和稳定的结构至关重要。理想的牙种植体制造方法应该在几分钟内制作出模具。 现代 3D 打印技术和适当的材料选择使该技术能够重建部分丢失的组织。该 I-Corps 项目基于开发可定制的光辅助 3D 打印平台，该平台允许快速制造基于聚合物的墨水和水凝胶。 该技术将用于制造稳定且功能性的（牙科）植入物。这种聚合物墨水基于材料中的光响应分子。该技术将利用传统水凝胶或聚合物前体中甲基丙烯酸酯基团的紫外线 (UV) 交联，以确保所选植入物的长期稳定性。该技术的优点包括：用于多组分生物材料的模块化室；非常快速地制造植入物、支架和手术工具；显着水平的控制创建和低成本产品。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优点和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Ink material selection and optical design considerations in DLP 3D printing

DLP 3D 打印中的墨水材料选择和光学设计注意事项

• DOI: 10.1016/j.apmt.2022.101721
• 发表时间: 2023-02
• 期刊: Applied Materials Today
• 影响因子: 8.3
• 作者: Goodarzi Hosseinabadi, Hossein;Nieto, Daniel;Yousefinejad, Ali;Fattel, Hoda;Ionov, Leonid;Miri, Amir K.
• 通讯作者: Miri, Amir K.

Ink Formulation and Selection for Biological Applications of Two-Photon Polymerization

双光子聚合生物学应用的墨水配方和选择

• DOI: 10.1021/acsaom.3c00165
• 发表时间: 2023-08-17
• 期刊: ACS Applied Optical Materials
• 作者: S. M. P;a;a;H. Hosseinabadi;Hoda Fattel;Umakanta Tripathy;A. Miri
• 通讯作者: A. Miri