Topologically Frustrated Polymer Dynamics and Phase Behavior of Polyzwitterions

拓扑受阻聚合物动力学和多两性离子的相行为

• 批准号: 2309539
• 负责人: Murugappan Muthukumar
• 金额: $ 52.5万
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2309539&HistoricalAwards=false
• 关键词: Topologically; Frustrated; Polymer; Dynamics; Phase

NON-TECHNICAL SUMMARYLarge molecules capable of carrying electrical charges are ubiquitous ever since life began on Earth. Such macromolecules are also vital in formulating environmentally friendly materials to guard global sustainability. However, experiments during the past century have shown that these molecules behave in mysterious ways that are difficult to understand and predict. These charged macromolecules in any system do not function alone, but all of them work together in collaborative manners. A fundamental understanding of such large scale cooperativity among many molecules is one of the grand challenges in physical and biological sciences. Towards mitigating this challenge, the PI will formulate a fundamental understanding of how electrically charged macromolecules move around in crowded electrolyte solutions, and how to facilitate them to form desirable structures toward novel water-based materials for societal benefits. In addition, the proposed activities include strong support of diversity and training a new generation of scholars and enable their future participation in industries on water-based materials and maintenance of global sustainability.TECHNICAL SUMMARYThe PI proposes experiments and theoretical developments to investigate hierarchical structure and dynamics of charged macromolecules, topologically frustrated non-diffusive dynamical state, coacervate gel composites, and assembly and phase diagrams for polyzwitterions, by combining light scattering, neutron scattering, fluorescence spectroscopy, fluorescence microscopy, impedance spectroscopy, rheology, single molecule electrophoresis, statistical mechanics, field theory, and several multi-scale simulation techniques. Specifically, the proposal addresses (a) the nature and origin of the newly discovered topologically frustrated dynamical state of polymers, and its transition into the other conventional dynamical modes, such as the Rouse-Zimm and reptation, (b) non-equilibrium forces to control formation of coacervate gel composites, and (c) dipolar interactions to understand assembly and phase behaviors of polyzwitterions. This project is aimed at understanding the intricate behaviors of charged macromolecular systems, and discovering new conceptual models for structure, dynamics, and transport in aqueous charged polymer systems. A fundamental understanding of the behavior of this important class of materials will help to design novel water-based polymeric materials to secure global sustainability with enhanced benefits to society. Training of graduate students and postdocs in this challenging research area is also an important component of the proposed activity. .This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

自从地球开始生命以来，能够携带电荷的非技术摘要分子无处不在。这种大分子对于制定环保材料以保护全球可持续性也至关重要。但是，过去一个世纪的实验表明，这些分子以难以理解和预测的神秘方式行事。这些在任何系统中都没有单独起作用，但它们都以协作的方式共同起作用。对许多分子之间如此大规模合作的基本理解是物理和生物科学的巨大挑战之一。为了缓解这一挑战，PI将对带电的大分子如何在拥挤的电解质解决方案中四处移动，以及如何促进它们形成理想的结构，以朝着新型的水性材料形成以获得社会利益的新颖材料。 In addition, the proposed activities include strong support of diversity and training a new generation of scholars and enable their future participation in industries on water-based materials and maintenance of global sustainability.TECHNICAL SUMMARYThe PI proposes experiments and theoretical developments to investigate hierarchical structure and dynamics of charged macromolecules, topologically frustrated non-diffusive dynamical state, coacervate gel composites, and assembly and phase diagrams for通过结合光散射，中子散射，荧光光谱，荧光显微镜，阻抗光谱，流变学，单分子电泳，统计力学，现场理论和几种多规模模拟技术，多氮杂型。具体而言，该提案解决了（a）新发现的拓扑沮丧的聚合物动力学状态的性质和起源，及其过渡到其他常规的动力学模式，例如Rouse-Zimm和Roptation，（b）非平衡力，以控制CoAcertate Gel Composites的形成凝胶组合互动，以及（c）二型偶性行为，以理解型二聚体的行为。该项目旨在了解带电的大分子系统的复杂行为，并在水性带电聚合物系统中发现新的结构，动力学和运输概念模型。对这种重要材料类别的行为的基本理解将有助于设计新型的水基聚合材料，以确保全球可持续性，并增强对社会的利益。在这个具有挑战性的研究领域对研究生和博士后的培训也是拟议活动的重要组成部分。该奖项反映了NSF的法定任务，并通过使用基金会的智力优点和更广泛的影响审查标准来评估值得支持。

项目成果

Electro-osmotic flow in nanoconfinement: Solid-state and protein nanopores

纳米限制中的电渗流：固态和蛋白质纳米孔

• DOI: 10.1063/5.0185574
• 发表时间: 2024
• 期刊: The Journal of Chemical Physics
• 作者: Li, Minglun;Muthukumar, Murugappan
• 通讯作者: Muthukumar, Murugappan

Topologically Frustrated Dynamical State of Polymers Trapped in Ideal Uniform Tetra-PEG Gels

• DOI: 10.1021/acs.macromol.3c01745
• 发表时间: 2023-11
• 期刊: Macromolecules
• 影响因子: 5.5
• 作者: Di Jia;Yui Tsuji;M. Shibayama;Murugappan Muthukumar