COLLABORATIVE RESEARCH: GCR: Characterization and Robust Multivariable Control of the Dynamics of Gas Exchange During Peritoneal Oxygenated Perfluorocarbon Perfusion

合作研究：GCR：腹膜全氟化碳灌注过程中气体交换动力学的表征和鲁棒多变量控制

基本信息

批准号：
2227939
负责人：
Joseph Friedberg
金额：
$ 138.13万
依托单位：
Temple University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2021
资助国家：
美国
起止时间：
2021-11-15 至 2027-09-30
项目状态：
未结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2227939&HistoricalAwards=false
关键词：
COLLABORATIVE RESEARCH GCR Characterization Robust

项目摘要

This Growing Convergence Research project addresses the critical societal need to develop a lung-independent technique for providing respiratory support to patients with respiratory failure from disorders such as COVID-19. Extracorporeal membrane oxygenation (ECMO) is the only such technique currently available, but is an expensive and scarce resource with complications that preclude it as an option for many patients, even when it is available. This project will develop a “third lung” technology that achieves lung-independent gas exchange by circulating oxygenated perfluorocarbon (PFC, a safe, inert liquid with extraordinary gas-dissolving properties) through the abdominal cavity. This is a convergent research project that integrates bioengineering and control theory with physiology to create a technology with the potential to save thousands of lives every year.Preliminary research results supported with an NSF EAGER award demonstrate potentially life-saving degrees of oxygenation and CO2 clearance. This project will push the research boundaries in three specific directions: (i) the development of a multi-functional fiber-optic sensor capable of measuring dissolved gas concentrations in PFC, as well as PFC temperature and pressure; (ii) the use of both benchtop and animal experiments to further characterize and model the fundamental dynamics of “third lung” gas exchange; and (iii) the development of novel robust multivariable control algorithms for the “third lung”, facilitating its potential implementation as a routine adjunct in the treatment of patients with respiratory failure. This convergent research portfolio will bring together a diverse research team from the fields of biomedical engineering, sensing, automatic control, and medicine in pursuit of research with high potential societal impact.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这一“日益融合的研究”项目解决了开发一种独立于肺的技术的关键社会需求，为因 COVID-19 等疾病而导致呼吸衰竭的患者提供呼吸支持。这是一种昂贵且稀缺的资源，其并发症使其无法成为许多患者的选择，即使该项目可用，该项目将开发一种“第三肺”技术，通过循环含氧全氟化碳（PFC，一种）来实现不依赖于肺的气体交换。这是一个融合研究项目，将生物工程和控制理论与生理学相结合，创造出一种每年有可能挽救数千人生命的技术。初步研究结果得到了支持。 NSF EAGER 奖证明了氧合和二氧化碳清除具有潜在的挽救生命的程度，该项目将在三个特定方向上推动研究界限：(i) 开发能够测量水中溶解气体浓度的多功能光纤传感器。 PFC 以及 PFC 温度和压力；(ii) 使用台式和动物实验来进一步表征和模拟“第三肺”气体交换的基本动力学；以及 (iii) 开发新型稳健的多变量控制算法这一融合研究组合将汇集来自生物医学工程、传感、自动控制和医学领域的多元化研究团队。具有高社会潜力的研究该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Safe Model-Based Multivariable Control of Peritoneal Perfusion

基于安全模型的腹膜灌注多变量控制

DOI：
10.1016/j.ifacol.2023.12.041
发表时间：
2023-01
期刊：
IFAC-PapersOnLine
影响因子：
0
作者：
Moon, Yejin;KadkhodaeiElyaderani, Behzad;Leibowitz, Joshua;Rezaei, Parham;Abdelazim, Eman M.;Awad, Morcos;Stachnik, Stephen;Stewart, Shelby;Friedberg, Joseph S.;Hahn, Jin;et al
通讯作者：
et al

Modeling the Impact of Animal Size on the Effectiveness of Peritoneal Oxygenation

模拟动物体型对腹膜氧合效果的影响

DOI：
10.1016/j.ifacol.2023.12.023
发表时间：
2023-01
期刊：
IFAC-PapersOnLine
影响因子：
0
作者：
Sarkar, Grace M.;Shaw, Anna E.;Fathy, Hosam K.
通讯作者：
Fathy, Hosam K.

320 Oxygenated Peritoneal Perfluorodecalin Improves Response to Normobaric Hypoxic Exposure in Swine

320 含氧腹膜全氟萘烷可改善猪对常压缺氧暴露的反应

DOI：
10.1017/cts.2023.371
发表时间：
2023-04
期刊：
Journal of Clinical and Translational Science
影响因子：
2.6
作者：
Leibowitz, Joshua L;Awad, Morcos A.;Stachnik, Stephen;Moon, Yejin;Kadkhodaeielyaderani, Behzad;Hahn, Jin;Fathy, Hosam K.;Stewart, Shelby J.;Friedberg, Joseph S.
通讯作者：
Friedberg, Joseph S.

Estimating the Impact of Peritoneal Perfluorocarbon Perfusion on Carbon Dioxide Transport Dynamics in a Laboratory Animal

评估腹膜全氟化碳灌注对实验动物二氧化碳传输动力学的影响

DOI：
10.23919/acc53348.2022.9867437
发表时间：
2022-01
期刊：
2022 American Control Conference
影响因子：
0
作者：
Doosthosseini, Mahsa;Moon, Yejin;Commins, Annina;Wood, Sam;Naselsky, Warren;Culligan, Melissa J.;Aroom, Kevin;Aroom, Majid;Shah, Akash;Bittle, Gregory J.;et al
通讯作者：
et al

Silicon ring resonator with ZIF-8/PDMS cladding for sensing dissolved CO2 gas in perfluorocarbon solutions

具有 ZIF-8/PDMS 包层的硅环谐振器，用于感测全氟化碳溶液中溶解的 CO2 气体