Collaborative Research: Combined Tribological and Bactericidal Effect of Bioinjectable Nanodiamonds on Biological Joints

合作研究：生物可注射纳米金刚石对生物关节的摩擦学和杀菌效果

• 批准号: 2242867
• 负责人: Donghui Zhu
• 金额: $ 11.97万
• 依托单位: SUNY at Stony Brook
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2242867&HistoricalAwards=false
• 关键词: Collaborative; Research; Combined; Tribological; Bactericidal

Collaborative Research: Combined Tribological and Bactericidal Effect of Bioinjectable Nanodiamonds on Biological JointsAbstract: PART 1: NON-TECHNICAL SUMMARYOsteoarthritis is a common condition that affects the joints, especially those in the hips and knees. As people age, the cartilage in their joints can break down, causing pain, stiffness, and reduced mobility. This makes performing everyday activities, like walking, climbing stairs, and even getting out of a chair, very difficult. Although there are treatments available for osteoarthritis, like oral pain medication and injections, they only provide temporary relief and do not cure the disease. As a result, surgery that replaces the damaged joint with an artificial one could be the only viable option. However, this surgery is a very difficult procedure that requires a lengthy recovery period and carries additional risks for seniors with underlying health conditions. Use of nanoparticles can potentially help in treating the early stages of tissue failures but there is a lack of knowledge about their interactions with biological tissues. That is why the goal of this project is to understand the processes happening upon nanoparticles contacting heathy and damaged tissues. The researchers propose to focus on diamond nanoparticles as a controlled system of study. The project will focus on understanding the mechanisms of interactions of these tiny particles with biological tissues and immune cell. In addition to the research itself, this project also aims to provide educational opportunities for students in the fields of materials science, biomedical engineering, and surface science. By engaging more students, especially women and minorities, the project will create a more diverse and inclusive scientific community, enabling new discoveries and innovations in the STEM fields.PART 2: TECHNICAL SUMMARYIn the early stages of osteoarthritis, the cartilage in the joints breaks down and the joint becomes inflamed, leading to pain and reduced mobility. One of the major challenges preventing the development of effective osteoarthritis treatment is the lack of understanding how the different mechanical, biochemical, and cellular processes within the joint interact with each other. This project aims to address this challenge by studying how diamond nanoparticles interact with joint cells and tissues to reduce damage and inflammation. The researchers will examine the effects of diamond nanoparticles on biological tissues and how they impact cell health as a function of the surface functionalization. The functionalized nanodiamonds will be analyzed for their ability to stay dispersed in body fluids and to escape macrophage attack to establish the correlation between the functionalization and the biocompatibility potential. Acquiring this essential knowledge will aid in comprehending the interactions between nanomaterials and biological cells, which will have a significant broader impact on the advancement of nanoparticle-based treatments and therapies. This will be particularly useful for treating joint-related conditions such as osteoarthritis, leading to decreased pain, improved mobility, and the prevention of further joint damage.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

协作研究：可生物注射的纳米座符对生物学关节提取物的摩擦学和杀菌作用结合在一起：第1部分：非技术摘要结构性关节炎是一种影响关节的常见疾病，尤其是臀部和膝盖的关节。随着人们的年龄，关节中的软骨会破裂，会导致疼痛，僵硬和移动性降低。这使得进行日常活动，例如步行，爬楼梯，甚至摆脱椅子，这非常困难。尽管有用于骨关节炎的治疗方法，例如口腔止痛药和注射，但它们仅提供暂时的缓解，并且不能治愈该疾病。结果，用人工替代受损关节的手术可能是唯一可行的选择。 但是，该手术是一个非常困难的程序，需要长时间的恢复期，并为患有潜在健康状况的老年人带来额外的风险。纳米颗粒的使用可能有助于治疗组织失败的早期阶段，但缺乏对它们与生物组织相互作用的了解。这就是为什么该项目的目标是了解接触希思和损坏组织的纳米颗粒上发生的过程的原因。研究人员建议将重点放在钻石纳米颗粒上，作为一种受控的研究系统。该项目将集中于理解这些微小颗粒与生物组织和免疫细胞的相互作用的机制。除研究本身外，该项目还旨在为材料科学，生物医学工程和表面科学领域的学生提供教育机会。通过吸引更多的学生，尤其是妇女和少数群体，该项目将创建一个更多样化和包容性的科学界，在STEM领域实现新的发现和创新。第2部分：技术总结骨关节炎的早期阶段，关节中的软骨破裂关节发炎，导致疼痛和迁移率减轻。阻止有效骨关节炎治疗发展的主要挑战之一是缺乏了解关节内不同机械，生化和细胞过程如何相互相互作用。该项目旨在通过研究钻石纳米颗粒如何与关节细胞和组织相互作用以减少损伤和炎症来应对这一挑战。研究人员将检查钻石纳米颗粒对生物组织的影响，以及它们如何影响细胞健康与表面功能化的关系。将分析功能化的纳米座孔，以使其保持在体液中的分散并逃避巨噬细胞攻击以建立功能化与生物相容性潜力之间的相关性。获取这一基本知识将有助于理解纳米材料与生物细胞之间的相互作用，这将对基于纳米粒子的疗法和疗法的进步产生更大的广泛影响。这对于治疗与联合相关疾病（例如骨关节炎）特别有用，导致疼痛减轻，改善移动性和预防进一步的联合损害。该奖项反映了NSF的法定任务，并被认为是通过基金会的知识分子来评估的值得支持的优点和更广泛的影响审查标准。