SBIR Phase II: Non-planar Spectral Breast Computed Tomography (CT)

SBIR 第二阶段：非平面光谱乳腺计算机断层扫描 (CT)

• 批准号: 2241912
• 负责人: Peymon Ghazi
• 金额: $ 100万
• 依托单位: MALCOVA INC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2241912&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Non; planar

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is to make available to the public a new imaging device that provides the anatomical and functional information necessary for effective and efficient diagnosis of breast cancer in women with dense breasts. The device employs a novel design and method of generating high-quality, three-dimensional images of the breast anatomy comfortably and at low levels of radiation dose. By design, the device will occupy a small space and support fast and efficient patient imaging. When commercialized, it can be priced on par with existing x-ray-based imaging technologies. Given these benefits and the large existing need nationwide need for a thorough dense-breast imaging solution, there is significant commercial potential. The prime objective of the project is to significantly increase the sensitivity and specificity in cancer radiological studies of women with dense breasts. Accordingly, this device has the potential to become the next generation breast cancer imaging modality of choice for small clinics as well as large hospitals, available to both patients and clinicians everywhere imaging is performed.This Small Business Innovation Research (SBIR) Phase II project supports development and validation of a comfortable, effective, dense-breast cancer imaging device built upon a new method and design for Computed Tomography (CT). This CT-based device does not require breast compression, and is smaller, faster, and higher in spatial resolution than alternative 3-dimensional imaging technologies. The instrument will provide spectral information used to distinguish deadly from non-deadly cancers from both dense and non-dense tissues across the entire breast, including regions near the chest and underarm. Nearly 50% of the U.S. female population has dense breasts. The most widely used technologies for breast imaging today —Mammography and Digital Breast Tomosynthesis — underserve these women. This technology cannot reliably image breast regions near the chest and underarm where cancers occur. Current methods also cannot reliably distinguish healthy, but dense, breast tissue from cancer. During this SBIR project, testing and validation of the developed device will be carried out using human-like surrogates called anthropomorphic phantoms. The company will demonstrate that this new technology provides high quality dense-tissue imaging, consistent whole-breast imaging, and spectral information that is of clinical benefit in cancer detection and diagnosis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）II期项目的广播公司影响/商业潜力是为公众提供一种新的成像装置，该设备为有效，有效的乳腺癌乳腺癌的乳腺癌提供了解剖和功能性信息。该设备采用了一种新颖的设计和方法，可以舒适地舒适地对乳房解剖结构和低水平的辐射剂量产生高质量的三维图像。根据设计，该设备将占据较小的空间，并支持快速有效的患者成像。当商业化时，它可以与现有的基于X射线的成像技术相提并论。鉴于这些好处以及全国范围内对彻底密集的成像解决方案的巨大需求，具有巨大的商业潜力。该项目的主要目的是显着提高乳房密集的女性癌症放射学研究的敏感性和特异性。根据该设备的统计，该设备有可能成为小型诊所以及大型医院的下一代乳腺癌成像模式，可供各地的患者和临床医生进行成像。这项小型企业创新研究（SBIR）II期项目支持开发和验证舒适，有效的，茂密的，密集的肉体成像设备，以新的方法和设计用于计算机进行了计算的媒介物（CT）（CT）。这种基于CT的设备不需要乳房压缩，并且比替代3维成像技术更小，更快且空间分辨率更高。该仪器将提供光谱信息，用于将致命的癌症与整个乳房（包括胸部附近的区域和腋下）区分开。美国女性近50％的乳房密集。当今用于乳房成像的最广泛使用的技术 - 摄影和数字乳房合成 - 能向这些妇女提供。这项技术无法可靠地图像胸部附近的乳房区域和在癌症发生的地方。当前的方法也无法可靠地区分健康但密集的乳腺组织与癌症。在这个SBIR项目中，将使用称为拟人化幻影的人类替代物进行测试和验证。该公司将证明，这项新技术提供了高质量的密集组织成像，一致的全胸成像以及在癌症检测和诊断方面具有临床益处的光谱信息。该奖项反映了NSF的法定任务，并被认为是通过基金会的知识分子优点和更广泛的影响审查标准来通过评估来通过评估来支持的。