CAREER: Smart and scalable approaches for developing multimodal optical and acoustic imaging technologies

职业：开发多模态光学和声学成像技术的智能且可扩展的方法

• 批准号: 2238878
• 负责人: Sri-Rajasekhar Kothapalli
• 金额: $ 52.87万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2238878&HistoricalAwards=false
• 关键词: CAREER; Smart; scalable; approaches; developing

In vivo imaging is an integral part of basic life science research and also plays a critical role in diagnosis of several diseases in clinic. Unlike in vitro diagnostics, in vivo imaging is non-destructive and repeatable, but typically provides information about one or two biological parameters at a given time. Study or detection of complex diseases in a living subject requires information about anatomical, functional (e.g., oxygen saturation), and molecular biomarkers. Therefore, multimodal imaging methods combining conventional imaging techniques - such as Magnetic Resonance Imaging, Position Emission Tomography and X-Ray Computer Tomography - have gained clinical importance. However, these multimodal technologies are expensive and not suitable for point-of-care (POC) imaging applications. This CAREER project will develop and integrate optical, ultrasound and photoacoustic technologies and demonstrate reliable multimodal POC imaging. The educational outreach activities will prepare female and underrepresented K-12, undergraduate, and graduate students for next generation biomedical imaging device innovation.The overarching goal of this proposal is to build an integrated research, education and outreach program centered on the science and engineering of next generation smart, affordable, portable, and non-ionizing, multimodal imaging and sensing devices. The research objective is to develop a novel multimodal optical, photoacoustic, and ultrasound imaging platform built at the interface of transparent ultrasound transducer technology, model-based data science tools and artificial intelligence. The platform will be validated for studying neural activity in brain cancer models. The educational objective is to prepare STEM leaders (at K-12, undergraduate and graduate levels) for advancing innovations in smart biomedical imaging and sensing devices through focused seminars and workshops for teachers, live demo of portable ultrasound imaging and inexpensive ultrasound bioreactor for cell stimulation, and new teaching materials at the intersection of multimodal sensing and AI.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

体内成像是基础生命科学研究不可或缺的一部分，在诊断诊所中的几种疾病中也起着至关重要的作用。与体外诊断不同，体内成像是无损且可重复的，但通常在给定时间提供有关一个或两个生物学参数的信息。研究或检测生命主题中的复杂疾病需要有关解剖学，功能（例如氧饱和）和分子生物标志物的信息。因此，结合常规成像技术的多模式成像方法（例如磁共振成像，位置发射断层扫描和X射线计算机断层扫描）已获得临床重要性。但是，这些多模式技术很昂贵，不适合护理点（POC）成像应用。这个职业项目将开发和整合光学，超声和光声技术，并展示可靠的多模式POC成像。教育宣传活动将为下一代生物医学成像设备创新的女性和人数不足的K-12，本科和研究生做好准备。该提案的总体目标是建立一项集成的研究，教育和外展计划，该计划以下一代智能，可负担，可承受的，便携式和非离子化的，多型的，多模型成像和多模型成像为基础的科学和工程。研究目标是开发一种新型的多模式光学，光声和超声成像平台，建立在透明超声传感器技术，基于模型的数据科学工具和人工智能的界面上。该平台将经过验证，用于研究脑癌模型中的神经活动。教育目标是通过针对老师的专注研讨会和讲习班，在智能生物医学成像和传感设备中的创新来准备STEM领导者（在K-12，本科和研究生水平），以推进智能生物医学成像和感应设备的创新，便携式超声成像的实时演示以及较低的超声激进生物反应器，以促进细胞刺激和新的教学材料，以及多种多样的型号，并在多种刺激和新的教学中奖励。使命，并被认为是通过基金会的知识分子优点和更广泛影响的审查标准通过评估值得支持的。