CAREER: Water-Soluble Metallofullerene Derivatives with Defined Structures and Tailorable Functions

职业：具有明确结构和可定制功能的水溶性金属富勒烯衍生物

• 批准号: 2238629
• 负责人: Jianyuan Zhang
• 金额: $ 70万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2238629&HistoricalAwards=false
• 关键词: CAREER; Water; Soluble; Metallofullerene; Derivatives

WIth support from the Macromolecular, Supramolecular, and Nanochemistry (MSN) Program of the Division of Chemistry, Jianyuan Zhang of Rutgers, The State University of New Jersey and his team will synthesize and structurally characterize water soluble endohedral metallofullerenes (EMFs) and explore their potential utility. EMFs are nanometer-sized soccer ball-shaped carbon molecules that encapsulate metal ions within their cages. Electronic, energy, quantum materials, catalysis, electronics, and biotechnologies are potential applications where EMFs show promise. However, realizing their full potential will require a better understanding of their behavior in aqueous solution. Typical approaches to making water-soluble EMF derivatives do not yield structurally defined molecules; they invariably disrupt the structure of the EMF cage and downgrade its electronic properties. This project will use a modular synthetic approach to create a family of water-soluble EMFs with precisely defined structures and study the correlation between their structural parameters and electro-optic properties. In the course of conducting this project, students will be trained in a multidisciplinary research environment. Active learning techniques with real world experiments that are integrated with the research results will be developed. Outreach activities targeting a diverse population in local community colleges will be carried out to introduce economically disadvantaged and underrepresented students future career paths in science.This project will utilize a modular “metallobuckytrio” (MBT) platform that was recently developed in the laboratory of the principal investigator. The MBT platform, which consists of two metallofullerenes covalently bonded to one C60 fullerene, allows the synthesis of a family of structurally defined water-soluble EMF derivatives with desirable properties via judicious selection of ligands. Three research aims will be pursued. In Aim 1, saccharide-functionalized ligands will be introduced to enhance the T1 relaxivity of gadolinium (Gd) MBTs for the next-generation MRI contrast agents. In Aim 2, porphyrin-functionalized ligands will be introduced and photo-induced charge separation and recombination processes of the resulting porphyrin-fullerene tridecads will be investigated. In Aim 3, dye-functionalized ligands will be introduced to form synergistic photosensitizers with potential long term scientific impact in photodynamic therapy (PDT).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在大分子，超分子和纳米化学（MSN）化学系的支持下，新泽西州立大学及其团队将合成并结构化水或结构表征水属性的内膜金属（EMFS），并探索潜在的ITERITY estore Unitiality。 EMF是纳米尺寸的足球球形碳分子，将金属离子包装在其笼子内。电子，能量，量子材料，催化，电子和生物技术是EMF表现出希望的潜在应用。但是，意识到他们的全部潜力将需要更好地理解其在水溶液中的行为。制造水溶性EMF衍生物的典型方法不会产生结构定义的分子。它们总是破坏EMF笼的结构并降级其电子性能。该项目将使用模块化的合成方法来创建具有精确定义结构的水溶性EMF家族，并研究其结构参数与电流特性之间的相关性。在进行该项目的过程中，学生将在多学科研究环境中接受培训。将开发与研究结果集成的现实世界实验的主动学习技术。针对当地社区大学多元化人群的外展活动将进行，以引入经济弱势群体和代表性不足的学生的科学领域的未来职业道路。该项目将利用一个模块化的“ metallobuckytrio”平台（MBT）平台，该平台最近在主要研究员的实验室中开发。 MBT平台由两个金属氟烯共同粘结到一个C60富勒烯，允许合成一个结构定义的水溶性EMF衍生物一家，并通过明智的配体选择具有理想的特性。将追求三个研究目标。在AIM 1中，将引入糖官能化的配体，以增强下一代MRI对比剂的Gadolinium（GD）MBT的T1松弛性。在AIM 2中，将引入卟啉官能化的配体，并将研究所得的卟啉 - 富勒烯Tridecads的光诱导的电荷分离和重组过程。在AIM 3中，将引入染料功能化的配体，以形成与光动力疗法（PDT）潜在的长期科学影响的协同光传感器（PDT）。该奖项反映了NSF的法定任务，并被认为是通过基金会的知识分子优点和更广泛影响的审查标准来通过评估来通过评估来支持的。