SBIR Phase II: Development of eco-friendly peptide bioprotectant for devastating late blight control

SBIR 第二阶段：开发环保型肽生物保护剂，用于毁灭性晚疫病控制

• 批准号: 2233590
• 负责人: Jiarui Li
• 金额: $ 99.71万
• 依托单位: INNATRIX, INC.
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2233590&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Development; eco

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project will be to control several critical pathogens and pests on multiple crops, in order to help feed the growing world population more sustainably. The global crop pest and disease control landscape is facing big challenges: many diseases are not well controlled and important chemical pesticides are restricted or banned due to their toxicity. There is a critical need for new types of disease control products that will be effective and will not harm the environment or human health. This proposal will lead to the development of a platform that can quickly generate new products to target poorly controlled pathogens, mitigating the development of resistant pathogens. This solution will increase farmers’ productivity and reduce their financial losses, while ensuring a more secure food supply.The proposed project will identify ecologically-safe peptides that will protect crops from diseases. The peptides will be designed to bind to, and interfere with, the function of proteins that the disease organisms produce, and which are essential to the disease process. The peptides will be designed to bind only to those proteins, so they will not have off-target effects. The ability to rapidly design and test such peptides will make it possible to target multiple proteins from a pathogen, reducing the risk that the pathogen will develop resistance. It will also be possible to target a wide range of diseases with similar life cycles, providing farmers with broad protection. The project will choose the optimum target proteins, design the peptides, and optimize the peptides to maximize binding to the targets. The peptides will be tested for their ability to prevent infection in the lab, and then will be produced at a larger scale and tested under the field conditions. The peptides will also be tested for safety as required for regulatory approval.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）II期项目的更广泛的影响/商业潜力将是控制多种农作物上的几种关键病原体和害虫，以帮助更可持续地养活不断增长的世界人群。全球农作物害虫和疾病控制局势面临着巨大的挑战：许多疾病受到控制，并且重要的化学农药因其毒性而受到限制或禁止。对于新型疾病控制产品的迫切需要，这些产品将有效，不会损害环境或人类健康。该提案将导致一个平台的发展，该平台可以迅速生产新产品以靶向控制不良的病原体，从而减轻耐药病原体的发展。该解决方案将提高农民的生产力并降低其财务损失，同时确保食品供应更安全。拟议的项目将确定可保护农作物免受疾病的生态安全辣椒。辣椒将被设计为与疾病生物产生的蛋白质的功能结合并干扰对疾病过程至关重要的蛋白质功能。辣椒的设计只能与这些蛋白质结合，因此它们不会具有脱靶效应。快速设计和测试此类辣椒的能力将使从病原体中靶向多种蛋白质，从而降低病原体发展抗性的风​​险。还可以针对具有类似生命周期的各种疾病，从而为农民提供广泛的保护。该项目将选择最佳目标蛋白，设计胡椒粉，并优化胡椒粉以最大程度地结合目标。 Pepperides将测试其防止实验室感染的能力，然后在较大的规模下生产并在现场条件下进行测试。批准。该奖项反映了NSF的法定使命，并通过使用基金会的知识分子优点和更广泛的影响审查标准来评估，以诚实的支持。