I-Corps: Enhancing Sensory Processing via Noninvasive Neuromodulation

I-Corps：通过无创神经调节增强感觉处理

• 批准号: 2232149
• 负责人: Qi Wang
• 金额: $ 5万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2232149&HistoricalAwards=false
• 关键词: Corps; Enhancing; Sensory; Processing; via

The broader impact/commercial potential of this I-Corps project is the development of technology that accurately perceives details of tactile, auditory, and visual stimuli required for completing the tasks necessary for daily life and independent living. Impaired sensory processing may cause misperceptions and miscommunication that can be frustrating, debilitating, and dangerous. This technology rapidly modulates sensory processing and could provide an immediate benefit across many potential use cases. By restoring clear sensory processing, this technology seeks to facilitate a return to socializing, exercise, hobbies, and employment for many individuals who have withdrawn from those activities due to chronic sensory issues. An enhancement of sensory processing may improve the ability to communicate easily, ambulate safely, and handle objects with dexterity.This I-Corps project is based on the development of a method of rapidly enhancing the accuracy and detail of sensory information processed in the brain via a noninvasive neuromodulation technique. In both animal and human studies, enhanced sensory processing translated to increased sensory acuity as evidenced by improved performance on sensory tasks. This technology includes wearable neural stimulation patches that could treat a variety of clinical causes of impaired sensory processing. This patches cause tonic activation of the locus coeruleus-norepinephrine (LC-NE) system in the brain and have resulted in a rapid enhancement of thalamic sensory processing. This NE-enhanced sensory processing state increased the perceptual sensitivity of awake animals performing sensory tasks. The vagus nerve can be stimulated noninvasively in humans by delivering electric current transcutaneously, providing an effective and safe method of neuromodulation. This novel bioelectronic method of using continuous tonic VNS provides sensory enhancement on-demand.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该I-Corps项目的更广泛的影响/商业潜力是技术的开发，可以准确感知完成日常生活和独立生活所需的任务所需的触觉，听觉和视觉刺激的细节。感官处理受损可能会导致误解和误解，这可能会令人沮丧，衰弱和危险。 该技术迅速调节了感官处理，并可以在许多潜在用例中提供直接的好处。通过恢复清晰的感官处理，该技术试图促进许多因长期感官问题而退出这些活动的人的社交，运动，爱好和就业。增强感觉处理可能会提高轻松，安全行动和使用敏捷的对象的能力。该I-Corps项目基于一种通过非侵入性神经调节技术快速增强大脑中感觉信息的准确性和细节的方法的开发。在动物和人类研究中，增强的感官处理转化为增加的感觉敏锐度，这可以通过提高感官任务的表现所证明。该技术包括可穿戴的神经刺激斑块，这些斑块可以治疗感官处理受损的各种临床原因。这会导致大脑中核核甲基肾上腺素（LC-NE）系统的滋补激活，并导致丘脑感觉处理的快速增强。这种增强的感觉处理状态增加了执行感官任务的清醒动物的感知灵敏度。迷走神经可以通过经皮输送电流在人类中无创刺激，从而提供有效且安全的神经调节方法。这种新型的生物电子方法使用连续的补品VNS提供了按需的感觉增强。该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响审查标准，被认为值得通过评估来提供支持。