NSF-DFG Confine: Building functional supraparticles through directed assembly of nonspherical nanoparticles under confinement

NSF-DFG Confine：通过在限制下定向组装非球形纳米粒子来构建功能性超粒子

• 批准号: 2223453
• 负责人: Xingchen Ye
• 金额: $ 38.21万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2223453&HistoricalAwards=false
• 关键词: NSF; DFG; Confine; Building; functional

Nanoparticles are finding use in almost all sectors of our economy from personal care to drug delivery. Their utility arises from the ability to access new properties that depend on their size, shape, and precise arrangement – called self-assembly. Self-assembly of nanoparticles in confined geometries hold the promise to build functional materials and devices with important properties that are otherwise not available. This award is a collaboration between Indiana University in the United States and Friedrich-Alexander-Universität Erlangen-Nürnberg in Germany to create well-defined supraparticles consisting of tens to thousands of nonspherical nanoparticles through directed self-assembly within liquid droplets and small channels. This award will expand the toolbox of supraparticle-by-design and will lay the groundwork for future computational studies of nanoparticle assembly by incorporating realistic interactions. Broader impacts of this project emphasize collaboration between experimentalists and computational scientists to enhance graduate and undergraduate education through multidisciplinary research. Summer research opportunities will be provided to students from underrepresented groups. Interactive modules to illustrate basic concepts of self-assembly will be designed and presented at local science museums and festivals. The overall objective of this award is to advance the design and synthesis of supraparticles by leveraging confined geometries to control nanoparticle assembly. Three aims will be undertaken. First, experimental, and computational approaches for the assembly of nonspherical nanoparticles into discrete supraparticles using emulsion droplets as templates will be established. Second, emulsion droplets generated using conventional emulsification methods and microfluidics to achieve precision synthesis of supraparticles composed of non-centrosymmetric nanoparticles will be leveraged. Third, one-dimensional supraparticles with emergent chiral optical properties via crystallization under cylindrical confinement will be fabricated. The interplay between experiment, establishing improved synthesis and characterization protocols, and theory, advancing coarse-grained modeling and simulation algorithms, will improve the fundamental understanding of self-assembly pathways in spherical and cylindrical confinement. The findings obtained and insights gained will also have applications in other systems that are affected by geometric constraints, such as crystallization of water in pores, virus capsid formation, biomineralization, macromolecular organization, and molecular packing in cells.This project was awarded through the “Chemistry and Transport in Confined Spaces (NSF-DFG Confine)" opportunity, a collaborative solicitation that involves the National Science Foundation and Deutsche Forschungsgemeinschaft (DFG).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

纳米粒子在我们的经济几乎所有领域都有用途，从个人护理到药物输送，它们的用途源于获得取决于其尺寸、形状和精确排列的新特性的能力——称为自组装。该奖项是美国印第安纳大学和德国弗里德里希-亚历山大大学埃尔兰根-纽伦堡大学之间的合作项目。通过液滴和小通道内的定向自组装来创建由数十至数千个非球形纳米粒子组成的明确的超粒子，该奖项将扩展超粒子设计的工具箱，并为未来纳米粒子组装的计算研究奠定基础。通过结合现实的互动，该项目的更广泛的影响强调实验学家和计算科学家之间的合作，通过多学科研究来加强研究生和本科生的教育，为来自代表性不足的群体的学生提供暑期研究机会，以说明基本概念。该奖项的总体目标是通过利用有限的几何形状来控制纳米粒子的组装，从而推进超粒子的设计和合成。并将建立使用乳液液滴作为模板将非球形纳米粒子组装成离散超粒子的计算方法。其次，使用传统乳化方法和微流体产生乳液液滴以实现精度。第三，将利用由非中心对称纳米粒子组成的超粒子的合成，通过圆柱约束下的结晶来制造具有突现手性光学性质的一维超粒子，建立改进的合成和表征方案与理论之间的相互作用，从而推进粗加工。粒度建模和模拟算法将提高对球形和圆柱形约束中自组装路径的基本理解。所获得的发现和见解也将提高。在受几何约束影响的其他系统中也有应用，例如孔中水的结晶、病毒衣壳的形成、生物矿化、大分子组织和细胞中的分子堆积。该项目通过“密闭空间化学与运输”（NSF）授予-DFG Confine）”机会，这是一项涉及美国国家科学基金会和德国研究协会 (DFG) 的合作征集活动。该奖项反映了 NSF 的法定使命，并已通过使用基金会的智力优点和更广泛的影响审查标准进行评估，认为值得支持。

项目成果

Controlled Self-Assembly of Gold Nanotetrahedra into Quasicrystals and Complex Periodic Supracrystals

金纳米四面体受控自组装成准晶和复杂周期超晶

• DOI: 10.1021/jacs.3c05299
• 发表时间: 2023
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Wang, Yi;Chen, Jun;Li, Ruipeng;Götz, Alexander;Drobek, Dominik;Przybilla, Thomas;Hübner, Sabine;Pelz, Philipp;Yang, Lin;Apeleo Zubiri, Benjamin
• 通讯作者: Apeleo Zubiri, Benjamin