PFI-TT: Achieving efficient production of visible light from semiconductor nanocrystals in water

PFI-TT：实现水中半导体纳米晶体高效产生可见光

基本信息

批准号：
2147791
负责人：
Ming Tang
金额：
$ 25万
依托单位：
University of Utah
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2023-10-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2147791&HistoricalAwards=false
关键词：
PFI TT Achieving efficient production

项目摘要

The broader impact/commercial potential of this Partnerships for Innovation - Technology Translation (PFI-TT) project is a nanocrystal-based light absorber that converts near infrared (NIR) to visible light in biologically friendly aqueous media. This project addresses unmet needs in the life sciences where the deep targeted delivery of light to tissue is needed because it is currently impossible deliver violet light deep inside living mammals without surgery or using a very intense laser that exceeds the mammalian pain threshold. This project will advance the development of a prototype system. The ability to deliver violet light non-invasively centimeters below the skin will facilitate new ways to detect oxygen (hypoxia) and create inexpensive light sources for point-of-care (POC) diagnostics. Potential commercial applications include mapping neural networks, mitigating pain, artificially controlling the circadian rhythm, alleviating depression, and imaging physiological processes in preclinical research. Apart from impact in these large and growing billion-dollar markets, this innovation will enable new directions in the diverse academic fields of neuroscience, light-sheet imaging and circadian rhythm research. The proposed project will establish novel methods for stabilizing hydrophobic nanocrystals and molecular antennas in water. The goals are to realize state-of-the art photon upconversion quantum yields with this hybrid platform in aqueous media, as opposed to previous records in organic solvent. Research objectives include establishing a kinetic or thermodynamic barrier that isolates the semiconductor nanocrystals and molecular emitters from their aqueous surroundings while preventing quenching by ambient oxygen. The nano- or micro-vesicles or emulsions proposed here will be stabilized by fine-tuning the relative ratios of various components and their differing solubilities. The spin-triplet excited state necessary for high photon upconversion quantum yields will be protected against undesired quenching by oxygen with chemical barriers or additives.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该创新合作伙伴关系 - 技术转化 (PFI-TT) 项目的更广泛影响/商业潜力是一种基于纳米晶体的光吸收剂，可在生物友好的水介质中将近红外 (NIR) 转换为可见光。该项目解决了生命科学中未满足的需求，其中需要将光深度定向传输到组织，因为目前如果不进行手术或使用超过哺乳动物疼痛阈值的非常强的激光，就不可能将紫光传输到活体哺乳动物体内深处。该项目将推进原型系统的开发。在皮下几厘米处非侵入性传输紫光的能力将促进检测氧气（缺氧）的新方法，并为即时护理 (POC) 诊断创造廉价的光源。潜在的商业应用包括绘制神经网络图、减轻疼痛、人为控制昼夜节律、缓解抑郁症以及对临床前研究中的生理过程进行成像。除了对这些庞大且不断增长的数十亿美元市场的影响之外，这项创新还将为神经科学、光片成像和昼夜节律研究等不同学术领域带来新的方向。该项目将建立稳定水中疏水性纳米晶体和分子天线的新方法。目标是通过该混合平台在水介质中实现最先进的光子上转换量子产率，而不是之前在有机溶剂中的记录。研究目标包括建立动力学或热力学屏障，将半导体纳米晶体和分子发射体与其水环境隔离，同时防止周围氧气猝灭。这里提出的纳米或微米囊泡或乳液将通过微调各种组分的相对比例及其不同的溶解度来稳定。高光子上转换量子产率所需的自旋三重态激发态将通过化学屏障或添加剂来防止氧气的意外猝灭。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优势和更广泛的影响进行评估，被认为值得支持审查标准。