MPS-Ascend: Nickel/Photoredox-Catalyzed C(sp3)–C(sp3) Cross-Coupling Between Alkyl Halides and Activated Alcohols

MPS-Ascend：镍/光氧化还原催化的 C(sp3)→C(sp3) 烷基卤化物和活化醇之间的交叉偶联

• 批准号: 2213210
• 负责人: Melecio Perea
• 金额: $ 30万
• 依托单位: Perea, Melecio
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2213210&HistoricalAwards=false
• 关键词: MPS; Ascend; Nickel; Photoredox; Catalyzed

This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2). Melecio Perea is awarded a NSF Mathematical and Physical Sciences Ascending Postdoctoral Research Fellowship (NSF MPS-Ascend) to conduct a program of research and activities related to broaden participation by groups underrepresented in STEM. This fellowship to Dr. Perea supports the research project entitled "MPS-Ascend: Nickel/Photoredox-Catalyzed C(sp3)–C(sp3) Cross-Coupling Between Alkyl Halides and Activated Alcohols", under the mentorship of a sponsoring scientist. The host institution for the fellowship is the University of California Los Angeles, and the sponsoring scientist is Dr. Abigail Doyle. The proposed work intends to explore the merger of nickel and photoredox catalysis which is an effective strategy for functionalizing C(sp3) centers. The proposed work intends to develop alkyl-alkyl coupling in racemic form; pursue mechanistic investigations which will provide insight into the nature of the cross coupling; and provide an evaluation of the scope of the reaction and its potential applicability to medicinally relevant transformations. The work will be complemented by computational modeling in the form of multivariant linear regression analysis. The PI intends to mentor other graduate and undergraduate students from historically excluded backgrounds through participation in the NSF Alliance for Graduate Education and the Professoriate Research University Alliance at UCLA. This alliance aims to enhance diversity in academia by supporting predoctoral and postdoctoral researchers from minority backgrounds.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项是根据2021年《美国救援计划法》（公法117-2）全部或部分资助的。梅西奥·佩雷亚（Melecio Perea）被授予NSF数学和物理科学上升博士后研究奖学金（NSF MPS-ASCEND），以开展与STEM中代表性不足的小组扩大参与有关的研究和活动计划。在赞助科学家的心态下，佩里亚博士的这一奖学金支持题为“ MPS-ASCEND：MPS-ASCEND：镍/光毒素催化的C（SP3）–C（SP3）烷基卤化物和活化醇之间的交叉耦合”。奖学金的主持机构是加利福尼亚大学洛杉矶分校，赞助科学家是阿比盖尔·道尔（Abigail Doyle）博士。拟议的工作旨在探索镍和光电毒素催化的合并，这是官能化C（SP3）中心的有效策略。拟议的工作旨在以消极形式发展烷基 - 烷基偶联。进行机械调查，以洞悉交叉耦合的性质；并评估反应范围及其对药物相关转换的潜在适用性。这项工作将通过以多变量线性回归分析形式的计算建模来完成。 PI旨在通过参加NSF研究生教育联盟和UCLA的教授研究大学联盟，从历史上排除的其他毕业生和本科生进行心理其他研究生和本科生。该联盟旨在通过支持来自少数族裔背景的专业和博士后研究人员来增强学术界的多样性。该奖项反映了NSF的法定任务，并通过使用基金会的智力优点和更广泛的影响评估标准来评估，被认为是宝贵的支持。