MPS-Ascend: Nickel/Photoredox-Catalyzed C(sp3)–C(sp3) Cross-Coupling Between Alkyl Halides and Activated Alcohols

MPS-Ascend：镍/光氧化还原催化的 C(sp3)→C(sp3) 烷基卤化物和活化醇之间的交叉偶联

• 批准号: 2213210
• 负责人: Melecio Perea
• 金额: $ 30万
• 依托单位: Perea, Melecio
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2213210&HistoricalAwards=false
• 关键词: MPS; Ascend; Nickel; Photoredox; Catalyzed

This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2). Melecio Perea is awarded a NSF Mathematical and Physical Sciences Ascending Postdoctoral Research Fellowship (NSF MPS-Ascend) to conduct a program of research and activities related to broaden participation by groups underrepresented in STEM. This fellowship to Dr. Perea supports the research project entitled "MPS-Ascend: Nickel/Photoredox-Catalyzed C(sp3)–C(sp3) Cross-Coupling Between Alkyl Halides and Activated Alcohols", under the mentorship of a sponsoring scientist. The host institution for the fellowship is the University of California Los Angeles, and the sponsoring scientist is Dr. Abigail Doyle. The proposed work intends to explore the merger of nickel and photoredox catalysis which is an effective strategy for functionalizing C(sp3) centers. The proposed work intends to develop alkyl-alkyl coupling in racemic form; pursue mechanistic investigations which will provide insight into the nature of the cross coupling; and provide an evaluation of the scope of the reaction and its potential applicability to medicinally relevant transformations. The work will be complemented by computational modeling in the form of multivariant linear regression analysis. The PI intends to mentor other graduate and undergraduate students from historically excluded backgrounds through participation in the NSF Alliance for Graduate Education and the Professoriate Research University Alliance at UCLA. This alliance aims to enhance diversity in academia by supporting predoctoral and postdoctoral researchers from minority backgrounds.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项的全部或部分资金来源于《2021 年美国救援计划法案》（公法 117-2）。 Melecio Perea 被授予 NSF 数学和物理科学提升博士后研究奖学金 (NSF MPS-Ascend)，以开展以下项目：与扩大 STEM 中代表性不足的群体的参与相关的研究和活动。 Perea 博士的这项奖学金支持题为“MPS-Ascend：镍/光氧化还原催化的 C(sp3)–C(sp3) 烷基卤化物和活性醇之间的交叉偶联”，在赞助科学家的指导下。该奖学金的主办机构是加州大学洛杉矶分校，赞助者是科学家是 Abigail Doyle 博士，拟议的工作旨在探索镍和光氧化还原催化的合并，这是功能化 C(sp3) 中心的有效策略。打算开发外消旋形式的烷基-烷基偶联；进行机理研究，以深入了解交叉偶联的性质；并评估反应的范围及其对医学相关转化的潜在适用性。 PI 打算通过参与 NSF 研究生教育联盟和加州大学洛杉矶分校教授研究大学联盟来指导其他来自历史上被排斥背景的研究生和本科生。该联盟旨在通过支持来自少数族裔背景的博士前和博士后研究人员来增强学术界的多样性。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。