SBIR Phase II: A novel, low-cost, noninvasive device to detect and characterize the presence or absence of a bolus in the upper esophagus.

SBIR II 期：一种新型、低成本、无创设备，用于检测和表征上食道中是否存在食团。

• 批准号: 2208084
• 负责人: Andrew Wilcox
• 金额: $ 100万
• 依托单位: REFLODX, INC.
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-15 至 2024-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2208084&HistoricalAwards=false
• 关键词: SBIR; Phase; II; novel; low

This Small Business Innovation Research (SBIR) Phase II project seeks to develop a novel noninvasive device for detecting and diagnosing gastroesophageal reflux. Reflux occurs when a bolus of gastric contents flows from the stomach into the esophagus. Symptoms of reflux can include chronic cough, choking, difficulty breathing or swallowing, upper airway infections, and chest pain. These symptoms can also be associated with other serious medical conditions. The proposed technology will aid clinicians in quickly being able to assess their patients’ symptoms and determine if reflux is the underlying cause. A noninvasive diagnostic modality for assessing reflux could save the healthcare system $10 billion annually, allow clinicians to provide improved care to their patients, and reduce the out-of-pocket costs of the 80 million Americans who are affected by reflux-related symptoms. This Small Business Innovation Research (SBIR) Phase II project will continue the development of a patented technology which uses pulse-echo ultrasound and proprietary algorithms in a non-conventional way to create an acoustic signature. The acoustic signature can detect and differentiate a bolus in the esophagus. The esophagus distends in response to a bolus of material, eliciting the esophageal layers to change in respect to one another. These changes can be observed with ultrasound sensors placed externally on the skin. This project will develop and validate electronic hardware, software, and custom ultrasonic transducers.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）II期项目旨在开发一种新型的无创设备，用于检测和诊断性胃食管反射。当胃含量的推注从胃中流入食道时，就会发生反流。 Reffernx的症状可能包括慢性咳嗽，窒息，呼吸困难或吞咽，上气道感染和胸痛。这些症状也可能与其他严重的医疗状况有关。拟议的技术将帮助临床医生迅速评估患者的症状，并确定Refflexx是否是根本原因。用于评估Refflexx的无创诊断方式可以节省每年100亿美元的医疗保健系统，使临床医生能够为患者提供改进的护理，并降低受反射相关症状影响的8000万美国人的自付费用。这项小型企业创新研究（SBIR）II期项目将继续开发一项专利技术，该技术以非规定的方式使用Pulse-Echo超声和专有算法来创建声学签名。声学特征可以检测和区分食道中的推注。食道响应材料推注的响应，引起食道层以相互改变。可以通过外部放置在皮肤上的超声传感器来观察这些变化。该项目将开发和验证电子硬件，软件和自定义超声波传感器。该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响标准，被视为通过评估而被视为珍贵的支持。