Biomimetic Sensors, Catalysts, and Materials: Chemistry at the Bio/Abio Interface

仿生传感器、催化剂和材料：Bio/Abio 界面的化学

• 批准号: 2203414
• 负责人: Lauren Webb
• 金额: $ 46.42万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2203414&HistoricalAwards=false
• 关键词: Biomimetic; Sensors; Catalysts; Materials; Chemistry

With support from the Macromolecular, Supramolecular and Nanochemistry Program (MSN) in the Division of Chemistry, Professor Lauren Webb of The University of Texas at Austin is combining surface chemical synthesis and advanced chemical analytics tools to study how proteins behave in abiological contexts. Integrating biological molecules into artificial environments allows biologically relevant function to be combined with synthetic materials in order to incorporate, rather than replicate, these capabilities in an artificial context. At this so-called “bio/abio” interface, basic biological functions can be co-opted to detect analytes with exceptional sensitivity or to catalyze the synthesis of useful molecules under environmentally friendly reaction conditions. Professor Webb and her students are addressing the central challenges of preparing and characterizing these systems by combining synthetic and biological chemistry. Their discoveries could lead to new approaches for protein-based sensors, catalysts and biomaterials as they develop characterize, manipulate, and explore an entirely new generation of biologically functional materials. Professor Webb is the State Director of the Welch Summer Scholars Program (WSSP), a 39-year program that provides rising high school students in the state of Texas with an authentic, significant, and meaningful summer residential research experience in the chemical sciences. Broader Impacts activities over the next three years of this proposal will 1) develop an online summer seminar program designed for all Texas high school students and chemistry teachers; and 2) grow a WSSP alumni network for mentoring and career development of the extraordinary alumni base of this program.The long-standing, central challenge to creating biologically-inspired functional devices and materials is to integrate native biomolecular structure, dynamics, and function into an abiological environment; each “bio” and “abio” component carries its own unique set of properties that must interact in an entirely new context. Professor Webb and her students are studying the behavior of biomolecular-material interactions for each individual component to synthesize, characterize, and expand bio/abio science to sensing, catalysis, and synthesis of novel biological materials for a wide variety of potential applications. The students involved in this project will gain a wide range of experience in surface chemical synthesis and a suite of chemical analysis techniques including infrared spectroscopy, x-ray photoelectron spectroscopy (XPS), surface circular dichroism (CD) spectroscopy, neutron reflectometry (NR) and scanning probe microscopy.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学划分中的大分子，超分子和纳米化学（MSN）的支持下，得克萨斯州的Lauren Niversity教授升级了表面Chexal合成的高级化学分析工具工具工具工具工具工具工具工具工具在基于生物学上的生物学作用，使其在生物学上构成生物学作用。结合合成材料，在人工环境中，这些功能在所谓的“ Bio/Abio”界面中。她的学生通过合成和CAL化学来制定和表征系统的中心，他们的发现可能会导致基于蛋白质的新方法，并发展出特征，操纵和探索无入口的液化材料Wellch Summmers学者计划（WSSP）在得克萨斯州的高中生中，具有真实的，有意义的夏季居民研究经验。 1）为所有德克萨斯州设计的在线夏季研讨会计划。在生物学上启发的功能设备和材料是将天然的结构，动力学和功能整合到一个物质学环境中）UST在反对新的环境中相互作用。并将生物/ABIO科学扩展到感知各种潜在应用的埃里亚尔。 XPS）LAR二色性（CD）光谱，中子反射测定法（NR）和扫描探针显微镜。该奖项反映了NSF'SFLY的使命，并认为尽管基金会的智力优点和更广泛的影响审查了标准，但在评估中认为值得支持。

项目成果

Acetylcholinesterase Adsorption on Modified Gold: Effect of Surface Chemistry on Enzyme Binding and Activity

• DOI: 10.1021/acs.langmuir.3c00648
• 发表时间: 2023-07-13
• 期刊: LANGMUIR
• 影响因子: 3.9
• 作者: Correira，Joshua M.;Madeksho，Diane E.;Webb，Lauren J.
• 通讯作者: Webb，Lauren J.