Solution-State High Field DNP on Large Volume Samples: Sensitivity-Enchanced NMR for the Organic Chemist

大体积样品的溶液态高场 DNP：有机化学家的灵敏度增强 NMR

基本信息

批准号：
2203405
负责人：
Sungsool Wi
金额：
$ 45万
依托单位：
Florida State University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2025-07-31
项目状态：
未结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2203405&HistoricalAwards=false
关键词：
Solution State Field DNP Large

项目摘要

With support from the Chemical Measurement and Imaging (CMI) Program in the Division of Chemistry, Dr. Sungsool Wi and his team at the National High Magnetic Field Laboratory (NHMFL) at Florida State University are devising new methods to advance the capabilities of nuclear magnetic resonance (NMR) spectroscopy – a leading means of characterizing the structure and dynamics of organic molecules. Complementary innovative paths are being pursued to substantially improve the NMR sensitivity and to provide correspondingly lower limits of detection for a wider range of target molecules. If successful, these methods would provide new opportunities for characterizing molecules in many different areas of scientific and industrial applications, including studies of pharmaceuticals, metabolites in human and animal studies, natural products, food and polymer additives, and small molecules in natural crude oil. Tools developed will be made available to local and remote users of NHMFL. This project provides valuable training opportunities to participating student and postdoctoral trainees, including summer internships offering hands-on experience for undergraduate students. The Wi team has identified two independent, complementary approaches to enhancing the NMR signals of arbitrary molecules. One relies on the use of low-viscosity supercritical solvents to enable electron-to-nucleus Overhauser-based dynamic nuclear polarization (ODNP). The other relies on hitherto unknown relaxation processes arising in biradicals to enable transfers from two J-coupled electrons to one nucleus over a wide variety of fields and correlation times. The Wi group will leverage these technological and conceptual breakthroughs to enable sensitivity-enhanced DNP spectroscopy at high fields on ~100 μL solution-state samples containing dilute organic molecules, with the aim of potentially creating a new paradigm in NMR.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学划分的化学测量计划（CMI）的支持下，佛罗里达州立大学的Netic Field Laboratoration（NHMFL）的Sungsool Wi博士和团队正在剥夺推进核磁共振能力的新方法（NMR）光谱 - 表征有机分子的结构和动力学的领先手段，可以实质上改进并提供相应的下部限制，以使其成功的范围更大的范围。制药，人类和动物研究，天然产品，食物和聚合物的添加和小分子的科学和工业应用领域将使开发的工具可用。参与者的学生和后者的实习生提供了动手或本科生的方法。在各种领域的核对核上的两个J J J J J J J J J J J J J J J J J J J J型电子将利用技术和概念。使用基金会的智力优点和更广泛的影响标准，被认为是值得一提的。