Probing Facet Dependent Properties of Crystalline Nanomaterials and Interactions with Biomolecules using Hybrid AFM

使用混合 AFM 探测晶体纳米材料的晶面依赖性特性以及与生物分子的相互作用

• 批准号: 1756444
• 负责人: Wen Zhang
• 金额: $ 30万
• 依托单位: New Jersey Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1756444&HistoricalAwards=false
• 关键词: Probing; Facet; Dependent; Properties; Crystalline

Metallic semiconductor nanomaterials or nanoparticles, such as cerium dioxide, zinc oxide and titanium dioxide, are produced in high volume and have broad applications in commercial products and processes such as sunscreens, antimicrobial agents, solar energy conversion and catalysis. These nanomaterials exhibit remarkable properties important to their industrial applications. However, the same unique properties may also cause unexpected biological consequences (e.g., cellular injury and cell membrane disruption), which are commonly attributed to the intrinsic and/or extrinsic properties. Intrinsic properties include size, shape, surface area, chemical composition, crystallinity, electronic, and surface reactivity. Extrinsic properties include radical formation and dissolution, which depend on intrinsic properties and environmental factors. Understanding of the roles of nanomaterial properties in toxicity mechanisms is critical for establishing regulatory and manufacturing frameworks for safe and sustainable nanotechnology. This project will encompass a suite of innovative scanning probe approaches to unravel facet-level material properties and true "nano" effects. Ultimately, the research findings may not only promote the "safety-by-design" of nanotechnology, but also facilitate the tailored fabrication of functional nanomaterials in a wide array of applications such as catalysis, biomedicine, phototherapy, and drug delivery, where crystal facet engineering for nanomaterials plays a pivotal role. Other broader impacts include (1) developing new teaching modules, laboratory manuals, and interactive learning activities targeted at a diverse student population to increase the STEM workforce. (2) organizing nanotechnology themed workshop series and hands-on training on scanning probe microscopy. This effort will be made through academic-industrial collaborations to build a focal point for regional research and education consortium in sustainable nanotechnology. Remote participants will be effectively involved through live streaming the workshops and other interactive webinars; At a molecular level, any changes in the size or shape of nanomaterials could be associated with changes in their exposed crystallographic facets or lattice planes. Different orientations and distributions of crystal facets have been reported to vary surface charge, surface tension or hydrophobicity, photocatalytic activity and surface reactivity, which ultimately changes biological effects of nanomaterials. The central hypothesis of this research is that the commonly characterized nanomaterial properties (e.g., size, shape, and zeta potential) and their environmental or biological impacts may originate from differences in exposed crystallographic planes or facets and their associated surface structures, atomic configurations and characteristics. To validate this hypothesis, this project seeks to achieve the following specific objectives: (1) Investigate the dependence of crystal facet distribution on highly crystalline semiconductor nanomaterials with distinct morphologies (cube, octahedra and plate). (2) Quantify facet-level intrinsic properties such as photo reactivity, band structures, and hydrophobicity to better reveal facet-dependent or facet-controlled surface properties. (3) Demonstrate hybridized scanning probe techniques such as using an atomic force microscope combined with Raman and infrared spectrometry in localized surface physical and chemical mapping of nanomaterials. (4) Investigate mechanisms of biomolecular interactions (adsorption, binding and degradation) at exposed facets of nanomaterials to provide new insight into potential biological implications. Furthermore, these research outcomes will be incorporated into STEM education and workforce development.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

金属半导体纳米材料或纳米粒子，例如二氧化铈、氧化锌和二氧化钛，被大量生产，并在防晒霜、抗菌剂、太阳能转换和催化等商业产品和工艺中具有广泛的应用。这些纳米材料表现出对其工业应用很重要的显着特性。然而，相同的独特特性也可能导致意想不到的生物学后果（例如，细胞损伤和细胞膜破坏），这通常归因于内在和/或外在特性。内在特性包括尺寸、形状、表面积、化学成分、结晶度、电子和表面反应性。外在性质包括自由基的形成和溶解，这取决于内在性质和环境因素。了解纳米材料特性在毒性机制中的作用对于建立安全和可持续纳米技术的监管和制造框架至关重要。该项目将包含一套创新的扫描探针方法，以揭示面级材料特性和真正的“纳米”效应。最终，研究结果不仅可以促进纳米技术的“安全设计”，而且还可以促进功能纳米材料在催化、生物医学、光疗和药物输送等广泛应用中的定制制造，其中晶面纳米材料工程发挥着关键作用。其他更广泛的影响包括 (1) 针对不同学生群体开发新的教学模块、实验室手册和互动学习活动，以增加 STEM 劳动力。 （2）组织纳米技术主题研讨会系列和扫描探针显微镜实践培训。这项努力将通过学术与工业合作来实现，以建立可持续纳米技术区域研究和教育联盟的焦点。远程参与者将通过直播研讨会和其他互动网络研讨会有效参与；在分子水平上，纳米材料尺寸或形状的任何变化都可能与其暴露的晶面或晶面的变化有关。据报道，晶面的不同取向和分布会改变表面电荷、表面张力或疏水性、光催化活性和表面反应性，最终改变纳米材料的生物效应。这项研究的中心假设是，纳米材料的共同特征（例如尺寸、形状和 zeta 电位）及其环境或生物影响可能源于暴露的晶面或晶面及其相关表面结构、原子构型和特征的差异。为了验证这一假设，该项目力求实现以下具体目标：（1）研究晶面分布对具有不同形貌（立方体、八面体和板状）的高结晶半导体纳米材料的依赖性。 (2) 量化晶面级别的内在特性，例如光反应性、能带结构和疏水性，以更好地揭示晶面相关或晶面控制的表面特性。 (3) 展示混合扫描探针技术，例如使用原子力显微镜结合拉曼和红外光谱法进行纳米材料的局部表面物理和化学绘图。 (4) 研究纳米材料暴露面的生物分子相互作用（吸附、结合和降解）机制，为潜在的生物学影响提供新的见解。此外，这些研究成果将被纳入 STEM 教育和劳动力发展中。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Magnetotactic bacteria: Characteristics and environmental applications

趋磁细菌：特性和环境应用

• DOI: 10.1007/s11783-020-1235-z
• 发表时间: 2020-04-01
• 期刊: Frontiers of Environmental Science & Engineering
• 影响因子: 6.4
• 作者: Xinjie Wang;Yang Li;Jian Zhao;H. Yao;Siqi Chu;Z.X. Song;Zongxian He;Wen Zhang
• 通讯作者: Wen Zhang

Probing Surface Electrochemical Activity of Nanomaterials using Hybrid Atomic Force Microscope-Scanning Electrochemical Microscope (AFM-SECM)

使用混合原子力显微镜-扫描电化学显微镜 (AFM-SECM) 探测纳米材料的表面电化学活性

• 发表时间: 2020-04
• 期刊: Journal of visualized experiments
• 作者: Xiaonan Shi; Qingquan Ma
• 通讯作者: Qingquan Ma

Measurement of the surface hydrophobicity of engineered nanoparticles using an atomic force microscope

使用原子力显微镜测量工程纳米粒子的表面疏水性

• DOI: 10.1039/c8cp04676j
• 发表时间: 2018-01
• 期刊: Physical Chemistry Chemical Physics
• 影响因子: 3.3
• 作者: Fu, Wanyi;Zhang, Wen
• 通讯作者: Zhang, Wen

Effect of single atom Platinum (Pt) doping and facet dependent on the electronic structure and light absorption of Lanthanum Titanium Oxide (La2Ti2O7): A Density Functional Theory study

单原子铂 (Pt) 掺杂和晶面的影响取决于氧化钛镧 (La2Ti2O7) 的电子结构和光吸收：密度泛函理论研究

• DOI: 10.1016/j.susc.2021.121949
• 发表时间: 2022-01-01
• 期刊: Surface Science
• 影响因子: 1.9
• 作者: Qingquan Ma;Wen Zhang;Joshua Young
• 通讯作者: Joshua Young