Poly(phosphoester)s via Olefin Metathesis

通过烯烃复分解的聚（磷酸酯）

• 批准号: 251079065
• 负责人: Professor Dr. Frederik Wurm
• 金额: --
• 依托单位: Sustainable Polymer Chemistry Group
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/251079065?language=en
• 关键词: Poly; phosphoester; via; Olefin; Metathesis

This proposal describes the synthesis of several polyphosphoesters (PPEs) via olefin metathesis reactions. The aim of this proposal is to achieve control over molecular architecture and microstructure to control the degradation kinetics of this highly promising polymer class with respect to bioapplications. Linear poly(phosphate)s and -phosphonates will be synthesized via acyclic diene metathesis (ADMET) polymerization. Especially the synthesis of the poly(phosphonate)s is of high interest due to the altered hydrolysis kinetics compared to poly(phosphate)s and ADMET allows access to this class of polymers for the first time in a systematic manner. Further, the architecture will be altered by introducing branches in the polymer backbone. Different pathways for a branching ADMET polymerization (AB2, A2+B3 or B3 approaches) will be investigated to design PPEs with a variable degree of branching. All these novel materials will be applied for the synthesis of degradable nanoparticles that can be loaded with drugs etc. and tested in vitro.

该提案描述了通过烯烃元理解反应的几个聚磷酸酯（PPE）的合成。该提案的目的是控制分子结构和微观结构，以控制这种高度有希望的聚合物类的降解动力学。线性聚（磷酸盐）S和 - 磷酸盐将通过无环二烯分解（ADMET）聚合合成。特别是由于与聚（磷酸盐）S和ADMET相比，聚（磷酸）S的合成引起了很高的兴趣，因此可以系统地以系统的方式进入该类别的聚合物。此外，将通过在聚合物主链中引入分支来改变体系结构。将研究分支聚合聚合（AB2，A2+B3或B3方法）的不同途径，以设计具有不同分支程度的PPE。所有这些新型材料都将用于合成可降解的纳米颗粒，这些纳米颗粒可以加载药物等并在体外进行测试。

项目成果

Morphology and Thermal Properties of Precision Polymers: The Crystallization of Butyl Branched Polyethylene and Polyphosphoesters

• DOI: 10.1021/acs.macromol.5b02581
• 发表时间: 2016-02
• 期刊: Macromolecules
• 影响因子: 5.5
• 作者: Yijun Zheng;Hisachi Tien Tee;Yu-Fu Wei;X. Wu;M. Mezger;Shouke Yan;K. Landfester;K. Wagener

Main-chain poly(phosphoester)s: History, syntheses, degradation, bio-and flame-retardant applications

• DOI: 10.1016/j.progpolymsci.2017.05.004
• 发表时间: 2017-10-01
• 期刊: PROGRESS IN POLYMER SCIENCE
• 影响因子: 27.1
• 作者: Bauer, Kristin N.;Tee, Hisaschi T.;Wurm, Frederik R.
• 通讯作者: Wurm, Frederik R.

Poly(phosphonate)s via Olefin Metathesis: Adjusting Hydrophobicity and Morphology

• DOI: 10.1021/ma5013286
• 发表时间: 2014-07
• 期刊: Macromolecules
• 影响因子: 5.5
• 作者: T. Steinbach;E. Alexandrino;C. Wahlen;K. Landfester;F. Wurm

In-Chain Poly(phosphonate)s via Acyclic Diene Metathesis Polycondensation

• DOI: 10.1021/acs.macromol.6b00366
• 发表时间: 2016-05-24
• 期刊: MACROMOLECULES
• 影响因子: 5.5
• 作者: Bauer, Kristin N.;Tee, Hisaschi T.;Wurm, Frederik R.
• 通讯作者: Wurm, Frederik R.

Hyperbranched poly(phosphoester)s as flame retardants for technical and high performance polymers

• DOI: 10.1039/c4py00830h
• 发表时间: 2014-01-01
• 期刊: POLYMER CHEMISTRY
• 影响因子: 4.6
• 作者: Taeuber, Karoline;Marsico, Filippo;Schartel, Bernhard
• 通讯作者: Schartel, Bernhard