Sequence-controlled, multifunctional materials by living anionic polymerization of aziridines

氮丙啶活性阴离子聚合的顺序控制多功能材料

• 批准号: 271284690
• 负责人: Professor Dr. Frederik Wurm
• 金额: --
• 依托单位: Sustainable Polymer Chemistry Group
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/271284690?language=en
• 关键词: Sequence; controlled; multifunctional; materials; living

The proposal presents the sequence-controlled anionic polymerization of aziridines. To enable anionic ring-opening polymerization, the aziridine has to be activated by sulfonamides. For the first time different sulfonamides will be investigated with respect to their polymerization behavior and the first functional aziridine monomers for anionic polymerization are presented. The sulfonamide serves two functions: first to remove the acidic proton, i.e. as a protection group, and second to activate the ring by electron withdrawal. The activation has a direct influence on the reactivity of the active chain end (an azaanion), which will allow the first sequence-controlled anionic polymerization depending on the type of the activation group. Different functional groups will be attached to the aziridine (at the ring) and the polymerization behavior will be investigated. The resulting polysulfonamides will be hydrolyzed to release the respective polyamines. These materials will be investigated with respect to their DNA transfection activity. The establishment of a polymer (sequence) structure- DNA transfection activity relation will be conducted and compared to conventional non-viral gene transfection.

该提案介绍了序列控制的阿祖里丁的阴离子聚合。为了实现阴离子环的聚合，副岛必须被磺酰胺激活。首次将针对其聚合行为进行研究，并提出了首个用于阴离子聚合的功能性氮杂胺单体。磺酰胺具有两个功能：首先去除酸性质子，即作为保护组，其次是通过电子撤回来激活环。激活对活动链端（AZAANION）的反应性有直接影响，该反应性将允许第一个序列控制的阴离子聚合取决于激活组的类型。不同的官能团将附着在齐里丁（在环上），并将研究聚合行为。所得的多磺酰胺将被水解以释放各自的多胺。这些材料将根据其DNA转染活性进行研究。将建立聚合物（序列）结构 - DNA转染活性关系，并将其与常规的非病毒基因转染进行比较。

项目成果

Microwave-Assisted Desulfonylation of Polysulfonamides toward Polypropylenimine.

• DOI: 10.1021/acsmacrolett.8b00180
• 发表时间: 2018-05
• 期刊: ACS macro letters
• 影响因子: 5.8
• 作者: E. Rieger;Tassilo Gleede;A. Manhart;M. Lamla;F. Wurm

Multihydroxy Polyamines by Living Anionic Polymerization of Aziridines.

• DOI: 10.1021/acsmacrolett.5b00901
• 发表时间: 2016-01
• 期刊: ACS macro letters
• 影响因子: 5.8
• 作者: E. Rieger;A. Manhart;F. Wurm

The living anionic polymerization of activated aziridines: a systematic study of reaction conditions and kinetics

• DOI: 10.1039/c7py00436b
• 发表时间: 2017-05
• 期刊: Polymer Chemistry
• 影响因子: 4.6
• 作者: E. Rieger;Tassilo Gleede;Katja Weber;A. Manhart;M. Wagner;F. Wurm

Linear Well-Defined Polyamines via Anionic Ring-Opening Polymerization of Activated Aziridines: From Mild Desulfonylation to Cell Transfection.

• DOI: 10.1021/acsmacrolett.9b00792
• 发表时间: 2019-12
• 期刊: ACS macro letters
• 影响因子: 5.8
• 作者: Tassilo Gleede;Fangzhou Yu;Yingli Luo;Youyong Yuan;Jun Wang;F. Wurm

Aziridines and azetidines: building blocks for polyamines by anionic and cationic ring-opening polymerization

• DOI: 10.1039/c9py00278b
• 发表时间: 2019-06-28
• 期刊: POLYMER CHEMISTRY
• 影响因子: 4.6
• 作者: Gleede, Tassilo;Reisman, Louis;Wurm, Frederik R.
• 通讯作者: Wurm, Frederik R.