Collaborative Research: Electrochemical Ni-Catalyzed Reductive Biaryl Coupling: Mechanistic Studies to Enable Chemical Synthesis

合作研究：电化学镍催化还原联芳基偶联：实现化学合成的机理研究

• 批准号: 2154698
• 负责人: Daniel Weix
• 金额: $ 60万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2154698&HistoricalAwards=false
• 关键词: Collaborative; Research; Electrochemical; Ni; Catalyzed

With the support of the Chemical Catalysis program in the Division of Chemistry, a collaborative team including Daniel Weix and Shannon Stahl of the University of Wisconsin-Madison, Mohammad Rafiee of the University of Missouri-Kansas City, and Robert Paton of Colorado State University are studying new approaches toward the electrochemical synthesis of chemicals useful in polymers and agriculture. This collaborative project will use analytical and computational tools to shed light on how these reactions occur and what factors are important for success. The lessons learned will enable lower-cost, greener synthesis of important molecules using electricity in place of metal reductants. The research team will also work to improve equal representation in chemistry via several established Bridge and outreach programs. Finally, the team will teach the broader chemistry community about the new tools of organic electrochemistry through courses and short courses.This collaborative team from the University of Wisconsin-Madison, the University of Missouri-Kansas City, and Colorado State University is studying electrochemistry-driven nickel catalyzed reductive biaryl synthesis from a variety of aryl electrophiles. The research team will use a combination of stoichiometric organonickel studies, theory, and electroanalytical techniques to understand how each step in the biaryl synthesis (oxidative addition, transmetalation, reduction, and reductive elimination) is influenced by catalyst identity, conditions, and applied potential. This understanding will be used to drive further studies to improve catalyst turnover number, turnover frequency, and selectivity, including the development of cross-selective reactions, to make electrochemical reductive biaryl synthesis suitable for commercial scale-up in flow reactors. These studies will contribute to an improved understanding of nickel catalysis and electrosynthesis and the resulting reactions will be lower-cost, more green alternatives to the state-of-the-art biaryl syntheses that utilize unselective oxidation reactions, expensive precious metal catalysts, and reactive aryl nucleophiles.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系化学催化项目的支持下，包括威斯康星大学麦迪逊分校的 Daniel Weix 和 Shannon Stahl、密苏里大学堪萨斯城分校的 Mohammad Rafiee 和科罗拉多州立大学的 Robert Paton 在内的合作团队研究用于聚合物和农业的化学品的电化学合成新方法。该合作项目将使用分析和计算工具来阐明这些反应如何发生以及哪些因素对成功至关重要。吸取的经验教训将有助于利用电力代替金属还原剂以更低成本、更环保的方式合成重要分子。研究团队还将致力于通过几个已建立的桥梁和外展计划来改善化学领域的平等代表性。 最后，该团队将通过课程和短期课程向更广泛的化学界传授有机电化学的新工具。这个来自威斯康星大学麦迪逊分校、密苏里大学堪萨斯城分校和科罗拉多州立大学的合作团队正在研究电化学-由各种芳基亲电子试剂驱动镍催化还原联芳基合成。研究小组将结合化学计量有机镍研究、理论和电分析技术来了解联芳基合成中的每个步骤（氧化加成、金属转移、还原和还原消除）如何受到催化剂特性、条件和应用电位的影响。这一认识将用于推动进一步研究，以提高催化剂周转数、周转频率和选择性，包​​括开发交叉选择性反应，以使电化学还原联芳基合成适合在流动反应器中进行商业规模化生产。这些研究将有助于加深对镍催化和电合成的理解，所产生的反应将成为最先进的联芳基合成的更低成本、更绿色的替代品，联芳基合成利用非选择性氧化反应、昂贵的贵金属催化剂和反应性反应。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Recent Advances in Electrochemical, Ni‐Catalyzed C−C Bond Formation

• DOI: 10.1002/ijch.202300089
• 发表时间: 2023-07
• 期刊: Israel Journal of Chemistry
• 影响因子: 3.2
• 作者: Mareena C. Franke;D. Weix

Cyclic voltammetry and chronoamperometry: mechanistic tools for organic electrosynthesis

循环伏安法和计时电流法：有机电合成的机械工具

• DOI: 10.1039/d2cs00706a
• 发表时间: 2024
• 期刊: Chemical Society Reviews
• 影响因子: 46.2
• 作者: Rafiee, Mohammad;Abrams, Dylan J.;Cardinale, Luana;Goss, Zachary;Romero-Arenas, Antonio;Stahl, Shannon S.
• 通讯作者: Stahl, Shannon S.