LEAPS-MPS: Confinement of Organometallic Complexes within Structured Polymers for Site-Isolated Tandem Catalysis

LEAPS-MPS：将有机金属配合物限制在结构化聚合物中用于位点隔离串联催化

• 批准号: 2137584
• 负责人: Madalyn Radlauer
• 金额: $ 24.97万
• 依托单位: San Jose State University Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2137584&HistoricalAwards=false
• 关键词: LEAPS; MPS; Confinement; Organometallic; Complexes

This award is funded in whole or in part under the American Rescue Plan Act of 2021 (Public Law 117-2). In this project, funded by the Mathematical and Physical Sciences Directorate and housed in the Chemistry Division, Professor Madalyn Radlauer and her students at San Jose State University (SJSU) will work to develop new chemical systems that can be used for tandem catalysis. Tandem catalysis, in which two or more catalysts operate in tandem to enact multiple reactions in a single step, provides significant benefits to efficiency and atom economy, as no workup or change of conditions is needed as would be required for multistep syntheses. The challenge for developing tandem catalytic systems is that every component of both reactions must be compatible – catalysts, reagents, products, and solvents – and the catalysts must be able to function under the same conditions. Prof. Radlauer will also undertake an educational and mentoring program that will help broaden participation of students underrepresented in science, both in her research program and in her department at SJSU, which is a Hispanic Serving Institution.Prof. Radlauer is addressing the challenges of tandem catalysis by taking advantage of the three dimensional structure of star polymers to serve as scaffolds for catalysis, allowing for the site isolation of organometallic catalysts, shielding these highly reactive species, and thereby permitting tandem catalysis with incompatible catalysts. Alkane metathesis is specifically being targeted as a test tandem catalytic sequence for its potential as a green energy process. Prof. Radlauer proposes broadening participation activities that would include providing an interdisciplinary undergraduate research experience to URM students from San Jose State University (SJSU) and from local community colleges. She will also be involved in development of a mentoring program for URM students at SJSU.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项全部或部分由《2021 年美国救援计划法案》（公法 117-2）资助。在该项目中，由数学和物理科学理事会资助，并设在化学系，Madalyn Radlauer 教授和她的学生。圣何塞州立大学（SJSU）将致力于开发可用于串联催化的新化学系统，其中两种或多种催化剂串联运行以实现催化作用。一步合成多个反应，为效率和原子经济性提供了显着的好处，因为不需要像多步合成那样进行后处理或改变条件，开发串联催化系统的挑战是两个反应的每个组分必须兼容。 – 催化剂、试剂、产品和溶剂 – 并且催化剂必须能够在相同的条件下发挥作用。拉德劳尔教授还将开展一项教育和指导计划，以帮助扩大在科学领域代表性不足的学生的参与。拉德劳尔教授正在通过利用星形聚合物的三维结构作为催化支架来解决串联催化的挑战，从而实现位点隔离。有机金属催化剂，屏蔽这些高活性物质，并允许与不相容的催化剂进行串联催化，因其作为一种潜在的催化剂而被专门作为测试串联催化序列。 Radlauer 教授建议扩大参与活动，包括为圣何塞州立大学 (SJSU) 和当地社区学院的 URM 学生提供跨学科的本科研究经验，她还将参与 URM 指导计划的制定。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。