LEAPS-MPS: Light Tunable Redox-Active Hybrid Nanomaterial with Ultrahigh Catalytic Activity for Colorimetric Applications

LEAPS-MPS：具有超高催化活性的光可调氧化还原活性混合纳米材料，适用于比色应用

• 批准号: 2316793
• 负责人: Tuhina Banerjee
• 金额: $ 24.96万
• 依托单位: Missouri State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2316793&HistoricalAwards=false
• 关键词: LEAPS; MPS; Light; Tunable; Redox; LEAPS; MPS; Light; Tunable; Redox

In this project managed by the Chemistry Division at NSF, Professor Tuhina Banerjee and her students at Missouri State University will be developing a series of light-responsive nanoscale enzyme mimics for colorimetric applications. This research will provide fundamental understanding about the important physicochemical properties of the nanomaterials, structure-activity relationships and basics of reaction kinetics mechanisms. Synthesized nanomaterials and their catalytic activity will be investigated using a combination of experimental and theoretical approaches. The proposed research will find broader application in the development of ultrasensitive colorimetric assays for bioanalysis, environment and biomarker detection. This project will provide scientific opportunities to diverse cohort of students especially members of underrepresented minority groups through cutting-edge interdisciplinary research experiences. Further, the research will be integrated in undergraduate curriculum at Missouri State, where students will acquire diverse skills sets and get trained in synthetic and characterization techniques that will have huge impact on their overall career development. Outreach activities will also be initiated for local high school students through workshops and lab experiences with the aim of encouraging diverse students to consider STEM careers. Prof. Banerjee will develop a new approach for enhancing the catalytic performance of nanomaterials that in particular exhibit mixed-redox states. She and her students will synthesize a series of light responsive cerium oxide-based nanozymes and explore the surface chemistry of cerium oxide, and investigate how its catalytic activity changes with plasmonic tunability. These new hybrid redox-active nanostructures will offer advantages over nanoscale enzyme mimics and natural peroxidases that have low catalytic efficiency. Further, plasmonic characteristics in these nanostructures opens up the possibility of achieving ultrahigh catalytic activity in the presence of visible light through plasmonic excitations and introduces an innovative approach of controlling reaction kinetics in a precise fashion.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在由NSF化学部管理的该项目中，Tuhina Banerjee教授及其学生的学生将开发一系列轻质响应的纳米级酶模拟物质应用。这项研究将提供对纳米材料的重要理化特性，结构活性关系和反应动力学机制的基础知识的基本理解。合成的纳米材料及其催化活性将使用实验和理论方法的组合进行研究。拟议的研究将在开发用于生物分析，环境和生物标志物检测的超敏度测定法中更广泛的应用。该项目将通过尖端的跨学科研究经验为各种学生，特别是代表性不足的少数群体的成员提供科学机会。此外，这项研究将集成在密苏里州立大学的本科课程中，在那里学生将获得多样化的技能，并接受综合和表征技术的培训，这将对他们的整体职业发展产生巨大影响。还将通过研讨会和实验室经验为当地高中学生发起外展活动，以鼓励多样化的学生考虑STEM职业。 Banerjee教授将开发一种新方法，以增强纳米材料的催化性能，特别是纳米材料的催化性能。她和她的学生将综合一系列光反应式氧化岩含量的纳米酶，并探索氧化岩岩化学的表面化学，并研究其催化活性如何随着血浆可调节性的变化而变化。这些新的杂化氧化还原活性纳米结构将提供比催化效率低的纳米级酶模拟酶和天然过氧化物酶的优势。此外，这些纳米结构中的等离子体特性开辟了在存在的光线下通过等离子体激发在可见光的情况下实现超高催化活性的可能性，并引入了一种精确控制反应动力学的创新方法。本奖项颁发奖项反映了NSF的法定任务，并通过评估范围来反映出通过评估范围的范围，并通过评估了基础，并将其视为宽广的基础。