SBIR Phase II: Single wearable patch for cost-effective, reliable, and accurate home sleep apnea testing

SBIR 第二阶段：单个可穿戴贴片，用于经济高效、可靠且准确的家庭睡眠呼吸暂停测试

• 批准号: 2136470
• 负责人: Brennan Torstrick
• 金额: $ 99.59万
• 依托单位: HUXLEY MEDICAL, INC.
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2136470&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Single; wearable

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is to help patients with cardiorespiratory conditions, including sleep apnea and cardiac arrhythmia. The project will develop a wearable sensor platform to simultaneously diagnose and monitor conditions. Multiple physiological measurements are collected by a comfortable, wireless sensor patch, resulting in a convenient remote monitoring clinical framework. Interfacing sensor data with an efficient cloud-based provider portal and automated algorithms will enable rapid screening of the 24 million undiagnosed sleep apnea patients in the United States. The proposed innovation will also provide insight into the practical clinical benefits and efficiencies to be gained by bundling multiple comorbid or otherwise related diagnostic pathways into a single workflow, such as reducing time to treatment for comorbid atrial fibrillation. This remote monitoring bundle concept represents the only all-in-one device capable of servicing multiple highly pervasive health challenges in a method unobtrusive and user-friendly for both the patient and the provider - particularly for telemedicine applications made more urgent by the global pandemic.This Small Business Innovation Research (SBIR) Phase II project aims to develop a simple, accurate, cloud-connected wearable patch and collect clinical comparison data to develop automated, low-power algorithms to simultaneously detect sleep-disordered breathing, sleep stages, and cardiac arrhythmias. The project integrates materials science, mechanical engineering, and signal processing approaches to detect critical physiological signals from the torso, including oxygen saturation and several hemodynamic metrics. The project will also conduct studies that offer early insights into the clinical benefits of bundled workflows across cardiac and sleep medicine specialties.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）II期项目的更广泛的影响/商业潜力是帮助患有心脏疾病的患者，包括睡眠呼吸暂停和心律不齐。该项目将开发一个可穿戴的传感器平台，以同时诊断和监测条件。通过舒适的无线传感器补丁收集多个生理测量，从而实现了方便的远程监测临床框架。将传感器数据与有效的基于云的提供商门户和自动化算法的接口数据可以快速筛选美国的2400万未诊断的睡眠呼吸暂停患者。提出的创新还将洞悉通过将多个合并症或其他相关诊断途径捆绑到单个工作流程中的实际临床益处和效率，例如减少合并症心房颤动的治疗时间。这个远程监控捆绑包概念代表了唯一能够为患者和提供者毫不显眼和用户友好的方法提供多种高度普遍的健康挑战的多合一设备 - 尤其是对于全球大流行而言，远程医疗应用程序更加紧迫。这项小型企业创新研究（SBIR）II期项目旨在开发一个简单，准确，云连接的可穿戴贴片并收集临床比较数据，以开发自动化的，低功率心律不齐。该项目集成了材料科学，机械工程和信号处理方法，以检测躯干的关键生理信号，包括氧饱和度和几种血液动力学指标。该项目还将进行研究，以早期见解心脏和睡眠医学专业的捆绑工作流程的临床益处。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子和更广泛影响的评估审查标准来通过评估来获得支持的。