I-Corps: Electrostimulation-based process that uses weak alternative electric fields to stimulate and activate hair follicles in the scalp

I-Corps：基于电刺激的过程，使用弱的替代电场来刺激和激活头皮中的毛囊

• 批准号: 2114428
• 负责人: Xudong Wang
• 金额: $ 5万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2114428&HistoricalAwards=false
• 关键词: Corps; Electrostimulation; based; process; uses

The broader impact/commercial potential of this I-Corps project is the development of a wearable electrostimulation hair growth cap. The proposed development of flexible and wearable nanogenerator aims at powering wearable electronic devices from relevant body motions. The goal is to enable the possibility of bypassing the bulky and rigid battery systems that currently hinder the evolution of many electronic therapeutic devices toward a wearable system. It may lead to a platform technology providing self-powered and closed-loop electronics as a new wearable or implantable solution for achieving a variety of biomedical functions, such as health monitoring, information gathering, and providing therapeutic treatments. Further, the self-powered, closed-loop electrostimulation cap may become an effective solution to cure the hair loss problem that plagues many human beings across a broad age range worldwide with an anticipated global market of $12 billion in 2024.This I-Corps project is based on the development of a self-powered, electrostimulation technology that directly converts biomechanical energy from random human body motions into continuous electric pulses without involving any battery or regulative electronics. Due to its unique energy resource and pulsed bi-phasic electricity form, directly applying the generated electricity to achieve certain therapeutic treatments may becomes effective for hair growth. This technology is distinguished from other battery-driven devices by directly coupling the biomedical functions with biomechanical energy sources, forming a closed loop of both energy flow and function feedback. In such a closed-loop electrostimulation, the stimulations are automatically responsive and synchronized to corresponding body motions, and thus impose efficient therapeutic effects without external manipulations. Successful pre-clinical results have been demonstrated self-powered electrostimulation hair regrowth on rats and nude mice. In addition, the results showed that the technology improved the secretion of a few key growth factors related to hair follicle growth, alleviating hair keratin disorder, and increasing the number of active hair follicles. The proposed technology may bring a wearable, convenient, safe, and cost effective solution to enable electrostimulation treatments to reverse baldness.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该I-Corps项目的更广泛的影响/商业潜力是开发可穿戴式静电刺激帽。拟议的柔性和可穿戴纳米发育仪的开发旨在从相关的车身运动中为可穿戴的电子设备供电。目的是使绕过目前阻碍许多电子治疗设备发展到可穿戴系统的笨重且刚性的电池系统的可能性。它可能会导致平台技术，可提供自动和闭环电子设备作为新的可穿戴或可植入的解决方案，用于实现各种生物医学功能，例如健康监测，信息收集和提供治疗性治疗。 此外，自动闭环的电刺激上限可能成为治愈脱发问题的有效解决方案，在全球范围内困扰许多人类，预期的全球市场在2024年的全球市场中为120亿美元。该I-CORPS项目基于自我机械电力的发展，不断地转换生物机械的电力，而不是连续启动人机的动力，该项目是基于连续的，即连续启动的，即连续启动人物机能的动力，电子产品。由于其独特的能源和脉冲双重电力形式，直接应用产生的电力来实现某些治疗方法可能对头发生长有效。通过将生物医学功能与生物力学能源耦合，从而形成了能量流和功能反馈的封闭环，从而与其他电池驱动的设备区别开来。在这样的闭环电刺激中，刺激自动响应并同步到相应的身体运动，因此在没有外部操作的情况下施加了有效的治疗作用。成功的临床前结果已证明在大鼠和裸鼠上自供电的静脉刺激再生。此外，结果表明，该技术改善了与毛囊生长，减轻毛的角蛋白疾病以及增加活性毛囊的数量有关的一些关键生长因子的分泌。拟议的技术可能会带来可穿戴，方便，安全且具有成本效益的解决方案，以实现电刺激处理以逆转秃发。该奖项反映了NSF的法定任务，并被认为是通过基金会的知识分子和更广泛影响的评估审查标准来通过评估来获得支持的。