Collaborative Research: Characterization and Optimization of N-Heterocyclic Carbene Functionalized Nanoparticle Systems

合作研究：N-杂环卡宾功能化纳米颗粒系统的表征和优化

• 批准号: 2108330
• 负责人: Jon Camden
• 金额: $ 37.72万
• 依托单位: University of Notre Dame
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2108330&HistoricalAwards=false
• 关键词: Collaborative; Research; Characterization; Optimization; Heterocyclic; Collaborative; Research; Characterization; Optimization; Heterocyclic

With the support of the Macromolecular, Supramolecular, and Nanochemistry Program in the Division of Chemistry, Dr. David Jenkins of the University of Tennessee and Drs. Jon Camden and Gina Navoa Svarovsky of the University of Notre Dame explore the use of N-heterocyclic carbenes (NHCs) chemistry for the surface modification of gold nanoparticles. Gold nanoparticles, which are typically stabilized by charged molecules such as citrate or monolayers with thiol anchoring groups, are used in wide-ranging chemical, biological, and environmental technologies but use is limited by the inherent instability of the nanoparticles in water. Drs. Jenkins and Camden are identifying ways to overcome this limitation by using NHC ligands. To do so, they are using a top-down method that involves the initial coordination of these ligands to coinage metal ions before being transferred to gold nanoparticle surfaces. They are using a variety of characterization tools to evaluate this chemistry and to better understand what NHC ligands promote enhanced stability of the functionalized gold nanoparticles. Drs. Jenkins, Camden, and Svarovsky are pursuing a Teaching Fellows Residency program to create an immersive research experience in the research laboratories and a Student Engagement in Authentic Science (SEAS) program that engages middle school students with original scientific data.The research involves the synthesis, characterization, and transfer of metal NHC complexes to gold nanoparticle surfaces, the characterization of the resulting bonding and close packing of a library of NHC ligands on gold nanoparticles, and the subsequent evaluation of NHC-functionalized gold stability and longevity. All of these studies utilize a top-down approach wherein the gold nanoparticles are functionalized after isolated coinage metal NHC complexes have formed in solution. This universal, top-down strategy is expected to be broadly applicable to gold nanoparticles of varying shapes and sizes. This approach has the potential to overcome limitations associated with bottom-up functionalization steps where each individual reaction is typically optimized for a specific system. Gold nanoparticles functionalized with heterocyclic carbenes hold promise in the quest to overcome challenges faced by conventional surface chemistries.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系的大分子，超分子和纳米化学计划的支持下，田纳西大学和博士的戴维·詹金斯博士。巴黎圣母院的乔恩·卡姆登（Jon Camden）和吉娜·纳维奥阿·斯瓦罗夫斯基（Gina Navoa Svarovsky）探索了N-杂环卡宾斯（NHCS）化学的使用用于金纳米颗粒的表面修饰。通常由带电分子（例如柠檬酸盐或具有硫醇锚定基团的单层）稳定的金纳米颗粒，用于广泛的化学，生物学和环境技术，但使用受到水中纳米颗粒固有不稳定性的限制。博士。詹金斯（Jenkins）和卡姆登（Camden）正在确定使用NHC配体克服这一限制的方法。为此，他们使用的是一种自上而下的方法，该方法涉及这些配体的初始配位与固定金属离子之前，然后再转移到金纳米颗粒表面。他们使用多种表征工具来评估这种化学性质，并更好地了解哪些NHC配体促进了功能化的金纳米颗粒的稳定性。博士。 Jenkins, Camden, and Svarovsky are pursuing a Teaching Fellows Residency program to create an immersive research experience in the research laboratories and a Student Engagement in Authentic Sc​​ience (SEAS) program that engages middle school students with original scientific data.The research involves the synthesis, characterization, and transfer of metal NHC complexes to gold nanoparticle surfaces, the characterization of the resulting bonding and close packing of a library of NHC金纳米颗粒上的配体，以及随后对NHC官能化的金稳定性和寿命的评估。所有这些研究都采用了自上而下的方法，其中在溶液中形成了分离的造币金属NHC络合物后，金纳米颗粒在功能化。预计这种通用的自上而下策略将广泛适用于各种形状和大小的金纳米颗粒。这种方法具有克服与自下而上功能化步骤相关的限制，其中通常针对特定系统优化每个单独的反应。用杂环碳烯功能化的金纳米颗粒具有希望克服常规表面化学面临的挑战的希望。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛的影响审查标准来评估的支持。