Collaborative Research: N-Heterocyclic Carbene Functionalized Metal Films and Nanoparticles for Next-Generation Surface-Enhanced Spectroscopy and Sensing

合作研究：用于下一代表面增强光谱和传感的N-杂环卡宾功能化金属薄膜和纳米粒子

• 批准号: 1709881
• 负责人: Jon Camden
• 金额: $ 30万
• 依托单位: University of Notre Dame
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1709881&HistoricalAwards=false
• 关键词: Collaborative; Research; Heterocyclic; Carbene; Functionalized; Collaborative; Research; Heterocyclic; Carbene; Functionalized

In this project, funded by the Macromolecular, Supramolecular, and Nanochemistry program of the Chemistry Division, Professors Jon Camden and Marya Lieberman of the University of Notre Dame and Professor David Jenkins of the University of Tennessee are developing robust, reusable, and highly specific nanoparticles for ultrasensitive detection of chemical species in complex biological and chemical systems. To meet this challenge, special and unique chemical modification of the surface of these nanoparticles is done. After modification of the surfaces, these particles can be applied to serve as sensors for specific molecules. This effort is also focusing on devising new methods of analysis that can be used in low-resource environments and drug testing. The highly collaborative nature will benefit students working in these labs. The success of this research has the potential to impact a wide range of sensor applications such as imaging cells, detecting trace contaminants, and analyzing samples outside of a laboratory setting. The unique optical properties of plasmonic nanoparticles and plasmonic assemblies has driven an explosion of new sensing and imaging modalities over the past several decades. The wide-reaching impact of functionalized metallic nanostructures is evidenced by studies which range from fundamental research to commercial applications. In this work, a transformative functionalization approach based on N-heterocyclic carbenes is employed for surface-enhanced Raman spectroscopy (SERS). This collaborative effort specifically targets a regenerative sensor for hydrogen peroxide and an in vitro pH sensor with expanded range. Additionally, procedures are established that make NHC functionalized films and colloids available to a non-specialist audience by proposing a "one-pot" synthesis of modified surfaces from conventional imidazoliums. These demonstrations will showcase how effective this new technology is for the broader chemical sensing community.

在这个项目中，由化学部的大分子，超分子和纳米化学计划资助，巴黎圣母大学的乔恩·卡姆登（Jon Camden）和田纳西大学的玛丽亚·利伯曼（Marya Lieberman）以及田纳西大学的戴维·詹金斯（David Jenkins）的教授正在发展，可重复使用，高度特定的Nanaparticles，可用于化学物质和化学物质的化学物质和化学物质。 为了应对这一挑战，对这些纳米颗粒表面的特殊和独特的化学修饰进行了修饰。修饰表面后，这些颗粒可以用作特定分子的传感器。这项工作还重点是设计新的分析方法，这些方法可用于低资源环境和药物测试。 高度协作的性质将使在这些实验室工作的学生受益。 这项研究的成功有可能影响广泛的传感器应用，例如成像细胞，检测痕量污染物以及在实验室环境之外分析样品。 在过去的几十年中，等离子体纳米颗粒和等离子组件的独特光学特性引起了新的感应和成像方式的爆炸。 功能化金属纳米结构的广泛影响可以通过研究范围从基本研究到商业应用。 在这项工作中，采用了基于N-杂环碳烯的变换功能化方法进行表面增强的拉曼光谱法（SERS）。 这种协作努力专门针对过氧化氢的再生传感器和具有扩展范围的体外pH传感器。 此外，确定了通过提出从传统的咪次硫唑的修改表面的“一锅”综合，使非专业观众的NHC功能化膜和胶体可用。 这些演示将展示这项新技术对更广泛的化学传感社区的有效性。