Science of Co-Amorphous Molecular Glasses

共非晶分子玻璃科学

基本信息

批准号：
2105065
负责人：
Sindee Simon
金额：
$ 50.64万
依托单位：
North Carolina State University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2025-08-31
项目状态：
未结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2105065&HistoricalAwards=false
关键词：
Science Co Amorphous Molecular Glasses

项目摘要

Non-Technical SummaryCo-amorphous molecular glasses are a new class of materials that are composed of two or more types of different small molecules. Combining two or more of these types of molecules into extended solid-state materials leads to co-amorphous molecular glasses that have better properties than the individual component systems. By investigating how parameters such as molecular size, shape, flexibility, and chemical interaction sites impact the properties of glasses made from binary mixtures of different types of molecules, researchers at North Carolina State University provide a fundamental understanding of co-amorphous molecular glasses. These insights and novel materials have the potential to advance the use of co-amorphous molecular glasses in pharmaceutics, energetics, agrichemicals, and personal care products. Advantages of using co-amorphous molecular glasses include, for example for pharmaceutics, high bioavailability and high stability during storage. The project, which is supported by the Solid State and Materials Chemistry program in the Division of Materials Research, also includes training of two graduate students and undergraduate researchers in cutting-edge research in glass chemistry and physics, thermal analysis, and rheology. Additionally, as part of this award, Profs. Simon and McKenna organize a one-week-long soft materials camp for junior high school students. It is called "Exploring Materials and Recycling" and leverages the longstanding summer engineering camp program developed and managed by The Engineering Place (TEP) of the North Carolina State University College of Engineering. Technical SummaryThis research, which is supported by the Solid State and Materials Chemistry program in the Division of Materials Research, focuses on a wide range of binary co-amorphous molecular glasses in order to develop a framework for the rational design of new glassy solids with improved properties. The role of molecular size, shape, and flexibility on co-amorphous glass formation, as well as the importance of the strength of and mismatches in specific interactions, are examined by calorimetry, rheology, and spectroscopy for glasses created by combinations of pharmaceutical materials, mock energetics, and small molecule additives or excipients. Major unanswered questions in the field of co-amorphous molecular glasses are addressed, including how dynamic, thermodynamic, and kinetic properties, including the glass transition temperature (Tg), crystallization rates, and glass stability, are interrelated and influenced by molecular structure and interactions. In addition, thermodynamic activity coefficient models are used to relate the molecular interactions and the synergistic increases in Tg that are often observed in co-amorphous glasses. The stability of the co-amorphous glass against crystallization is modeled and characterized in the framework of the time-temperature-transformation (TTT) diagram using extensions of classical models of nucleation and growth kinetics. The importance of the work is in providing fundamental new knowledge for the nascent field of molecular glass engineering that is anticipated to facilitate the rational design of new glassy solids that can be engineered on demand for a given function.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

非技术摘要 - 肉体分子玻璃是一类新的材料，由两种或多种类型的不同小分子组成。将这两种类型的分子结合到扩展的固态材料中，导致具有比单个组件系统更好的性质的共生分子玻璃。通过研究分子大小，形状，柔韧性和化学相互作用等参数如何影响由不同类型分子的二元混合物制成的玻璃的性质，北卡罗来纳州立大学的研究人员对共同形态分子玻璃杯提供了基本的了解。这些见解和新颖的材料有可能在药物，能量学，农业化学产品和个人护理产品中推动使用共肉类分子玻璃的使用。使用共同形分子玻璃的优点包括药物，高生物利用度和储存过程中高稳定性。该项目得到了材料研究部的固态和材料化学计划的支持，还包括对两名研究生的培训和玻璃化学和物理学，热分析和流变学领域的尖端研究研究生的培训。此外，作为该奖项的一部分，教授。西蒙（Simon）和麦肯纳（McKenna）为初中学生组织了一个为期一周的软材料营。它被称为“探索材料和回收”，并利用了由北卡罗来纳州立大学工程学院的工程场所（TEP）开发和管理的长期夏季工程营计划。材料研究部的固态和材料化学计划支持的技术摘要研究重点是广泛的二进制共同颗粒分子玻璃，以开发一个框架，用于合理设计具有改进特性的新玻璃固体。分子大小，形状和柔韧性在共同玻璃形成中的作用，以及特定相互作用中强度和不匹配的强度和不匹配的重要性，通过量热法，流变学和光谱法对药物材料的组合，模拟能量和小分子添加剂或凝聚剂的组合创建的玻璃产生。在共同肉体分子玻璃领域的主要未解决问题，包括动态，热力学和动力学特性（包括玻璃过渡温度（TG），结晶速率和玻璃稳定性）如何相互关联并受到分子结构和相互作用的影响。另外，热力学活性系数模型用于将分子相互作用和TG中经常观察到的TG的协同增加。使用成核和生长动力学的经典模型的扩展，在时间温度转换（TTT）图的框架中对共晶玻璃对结晶的稳定性进行了建模和表征。这项工作的重要性在于为分子玻璃工程的新生领域提供基本的新知识，预计该领域有助于促进新玻璃固体的合理设计，可以根据需要使用基金会的知识优点和广泛的criperia criperia criperia criperia criperia criperia criperia criperia criperia criperia criperia criperia criperia criperia criperia rection this奖项可以根据需要进行特定功能进行设计。