SBIR Phase I: Blockchain-Enabled Clinical Registry Program

SBIR 第一阶段：区块链支持的临床注册计划

• 批准号: 2036317
• 负责人: Anthony Deasey
• 金额: $ 25.6万
• 依托单位: SOFTHREAD, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2022-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2036317&HistoricalAwards=false
• 关键词: SBIR; Phase; Blockchain; Enabled; Clinical

The broader impact and commercial potential of this Small Business Innovation Research (SBIR) project will develop novel cybersecurity for highly regulated industries and expand the applications of blockchain, focusing on enhancing and securing the exchange of medical data among different stakeholders. To date, medical consents can involve multiple parties: participant, medical center, physician, ethical review boards across various research institutions, and sponsors. Each group maintains independent systems, resulting in delays and potential for misuse of underlying clinical data. Additionally, minimal controls ensure the data input's completeness and accuracy, leading to lower confidence in and stagnation of the data and lost opportunity for real-world learning experiences. The proposed project proposes to establish a proof-of-concept decentralized, digital health data platform. It can be expanded to other highly regulated industries where it can improve the accuracy, confidentiality and security of data sets. This SBIR Phase I project will utilize blockchain immutability to provide an advanced electronic medical consenting service, ensuring the integrity of consenting transactions and a novel publish/subscribe and fine-grained, attribute-based access control to audit access to underlying datasets. Additionally, the project will employ novel approaches to encryption that can preserve the privacy of the transactions and messages that transit the system. The approach is built on emerging threshold cryptography standards, but proposes a novel vector-label-input threshold encryption. Today's labeled threshold encryption implementations only take a single string as a label, but a vector-label-input threshold encryption implementation will support a vector of strings as labels. This enables an innovative approach to fine-grained access control by allowing the system to check for any number of string-based attributes at the time the transactions are signed and committed into the ledger on the blockchain. To enable high-performance, total-order preserving data streams, the project will combine innovations in the publish/subscribe messaging pattern with state-of-practice blockchain technology platforms.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该小企业创新研究（SBIR）项目的更广泛影响和商业潜力将为高度监管的行业开发新颖的网络安全，并扩大区块链的应用，重点是增强和保护不同利益相关者之间的医疗数据交换。 迄今为止，医疗同意书可能涉及多方：参与者、医疗中心、医生、各个研究机构的伦理审查委员会和赞助商。每个小组都维护独立的系统，导致延误和潜在的基础临床数据的滥用。此外，最少的控制确保了数据输入的完整性和准确性，导致数据信心降低和停滞，并失去了现实世界学习体验的机会。 拟议项目建议建立一个概念验证的去中心化数字健康数据平台。 它可以扩展到其他受到高度监管的行业，从而提高数据集的准确性、保密性和安全性。该 SBIR 第一阶段项目将利用区块链的不变性来提供先进的电子医疗同意服务，确保同意交易的完整性，以及新颖的发布/订阅和细粒度、基于属性的访问控制来审计对底层数据集的访问。此外，该项目将采用新颖的加密方法，可以保护传输系统的交易和消息的隐私。该方法建立在新兴的阈值加密标准的基础上，但提出了一种新颖的矢量标签输入阈值加密。当今的标记阈值加密实现仅采用单个字符串作为标签，但向量标签输入阈值加密实现将支持字符串向量作为标签。这使得系统能够在交易签名并提交到区块链上的账本时检查任意数量的基于字符串的属性，从而实现细粒度访问控制的创新方法。为了实现高性能、全序保留的数据流，该项目将发布/订阅消息传递模式的创新与实践区块链技术平台相结合。该奖项反映了 NSF 的法定使命，并通过评估被认为值得支持利用基金会的智力优势和更广泛的影响审查标准。