Research Initiation Awards: Tailored Carbon Nanotubes-Supported Nickel Nanoparticles for Carbon-Carbon Bond Forming Reactions in Batch and Continuous Flow

研究启动奖：用于批量和连续流中碳-碳键形成反应的定制碳纳米管负载镍纳米粒子

基本信息

批准号：
2101126
负责人：
Ali Siamaki
金额：
$ 29.31万
依托单位：
Fayetteville State University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-15 至 2025-07-31
项目状态：
未结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2101126&HistoricalAwards=false
关键词：
Research Initiation Awards Tailored Carbon

项目摘要

Research Initiation Awards provide support for junior and mid-career faculty at Historically Black Colleges and Universities who are building new research programs or redirecting and rebuilding existing research programs. It is expected that the award helps to further the faculty member's research capability and effectiveness, improves research and teaching at the home institution, and involves undergraduate students in research experiences. The award to Fayetteville State University supports research in nanochemistry. More specifically, it supports research that investigates novel synthesis of heterogeneous catalysts where nickel is supported on carbon nanotubes. Furthermore, the project engages undergraduate engineering students in the research activities.The aim of this project is to develop a straightforward, simple, and cost-effective method for preparation of nickel nanoparticles supported on carbon nanotubes (Ni/MWCNTs) to serve as an efficient heterogeneous nanocatalyst for carbon-carbon cross coupling reactions. The method involves a dry mixing of the corresponding nickel salt with carbon nanotubes at ambient temperature without the necessity of any reducing agent or solvent under mechanical shaking of a ball-mill. Notably, both the transition metal and solid support used for making these nanocomposites are inexpensive and highly abundant. The as-prepared Ni/MWCNTs nanoparticles will be used for cross coupling reactions under batch and continuous flow process conditions. In this regard, the use of microwave energy will be investigated as an alternative, convenient, green, and efficient heating source to develop the necessary conditions for the catalytic reactions. The proposed research will not only address fundamental aspects of carbon-carbon bond formation reactions but will also aid in exploring the continuous flow technology (e.g., FlowLab) for translation to large-scale production of useful organic molecules. This section of the project will bring together the best techniques to develop a technology with direct industrial applicability and will expedite broader application of continuous throughput manufacture technologies for the synthesis of active pharmaceutical ingredients (APIs) through the major bond formation utilizing the cross-coupling catalysis in flow. This project is potentially beneficial to industrially relevant commercial applications and pharmaceutical industries, and thus expand the opportunities for future collaborations and partnerships with pharmaceutical companies.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

研究启动奖为历史悠久的黑人学院和大学的初级和中级教师提供了支持，他们正在构建新的研究计划，或重新指导和重建现有的研究计划。预计该奖项有助于进一步促进教职员工的研究能力和有效性，改善家庭机构的研究和教学，并让本科生参与研究经验。费耶特维尔州立大学的奖项支持纳米化学研究。更具体地说，它支持研究研究的研究，该研究研究了在碳纳米管上支持镍的异质催化剂的新合成。此外，该项目使本科工程专业的学生参与研究活动。该项目的目的是开发一种直接，简单且具有成本效益的方法，用于准备在碳纳米管（NI/MWCNTS）上支持的镍纳米颗粒（NI/MWCNTS），以作为有效的异质纳米型纳米质量纳米质量的碳替代碳替代碳替代碳碳替代。该方法涉及在环境温度下将相应的镍盐与碳纳米管混合，而无需在球磨机机械摇动下任何还原剂或溶剂。值得注意的是，用于制造这些纳米复合材料的过渡金属和固体支撑都是廉价且高度丰富的。准备的Ni/MWCNT纳米颗粒将用于批处理和连续流动过程条件下的交叉耦合反应。在这方面，将研究微波能的使用作为一种替代，方便，绿色和有效的加热来源，以开发催化反应的必要条件。拟议的研究不仅将介绍碳碳键形成反应的基本方面，而且还将有助于探索连续流技术（例如，流lab），以转化为大规模生产有用的有机分子。该项目的这一部分将汇集具有直接工业适用性的技术的最佳技术，并通过通过交叉耦合催化流量中的主要债券形成来加快更广泛的持续吞吐量制造技术来综合主动药品成分（API）。该项目可能对与工业相关的商业应用和制药行业有益，因此扩大了与制药公司的未来合作和合作伙伴关系的机会。该奖项反映了NSF的法定任务，并被认为是通过基金会的知识分子优点和更广泛的影响审查标准来通过评估来通过评估来支持的。