Pathophysiology Crystal-induced kidney injury

病理生理学 晶体引起的肾损伤

• 批准号: 246278195
• 负责人: Professor Dr. Hans-Joachim Anders
• 金额: --
• 依托单位: Medizinische Klinik und Poliklinik IV
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/246278195?language=en
• 关键词: Pathophysiology; Crystal; induced; kidney; injury

Crystals can induce kidney injury in many different ways, e.g. during cholesterol embolism, intratubular crystallization or during urolithiasis. In the previous project we were able to generate important data on calcium oxalate crystal-induced kidney inflammation. Here we propose systematic studies on the activation and injury of renal immune and non-immune cells induced by a great variety of clinically relevant crystals. In addition, we will explore innovate disease models of cholesterol embolism of the kidney and urate nephropathy. Furthermore, we will explore the molecular mechanisms of crystal granuloma formation. By the help of systematic studies this project will unravel the molecular pathophysiology of crystal nephropathies.

晶体可以以许多不同的方式诱导肾脏损伤，例如在胆固醇栓塞期间，肾小管内结晶或尿石病期间。在上一个项目中，我们能够生成有关草酸钙晶体诱导的肾脏炎症的重要数据。在这里，我们提出了有关由多种临床相关晶体诱导的肾脏免疫和非免疫细胞激活和损伤的系统研究。此外，我们将探索肾脏和尿酸肾病的胆固醇栓塞的创新疾病模型。此外，我们将探索晶体肉芽肿形成的分子机制。在系统研究的帮助下，该项目将揭示晶体肾病的分子病理生理。