CAREER: Scalable, high-precision optoelectronic lab-on-a-chip towards next-generation precision therapeutics

职业：可扩展、高精度光电芯片实验室，致力于下一代精准治疗

• 批准号: 2046031
• 负责人: Guangyu Xu
• 金额: $ 50万
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2046031&HistoricalAwards=false
• 关键词: CAREER; Scalable; precision; optoelectronic; lab

Precision therapeutics will benefit from biomedical devices that can acquire cellular/molecular information specific to targeted patient groups. This research project aims to establish scalable, high-precision lab-on-a-chip technologies that will ultimately lead to enabling tools in next-generation precision therapeutics. The outcome of this research will result in new engineering tools and disease related assays that will likely make an impact in pharmatheutical screening, immunotherapeutic development, and point-of-care systems. The educational objectives of this proposal are aimed at training and inspiring young engineers and scientists who are equipped with the multidisciplinary background required to help define the future trajectory of personalized medicine, neuroengineering, and point-of-care systems. The broader impacts of this project include: 1) advancing transformative device technologies for scalable, high-precision lab-on-a-chip systems and providing powerful tools for pharmatheutics and point-of-care testing; 2) educating underrepresented undergraduate and graduate researchers to contribute to the nation’s workforce needs in bioengineering and healthcare; 3) contributing to the K-12 science, technology, engineering, and mathematics education by weekend seminars and mentoring student-teacher pairs from local middle schools; and 4) promoting biological sciences and biotechnology among local senior citizens and support groups for neurological diseases and immunological disorders. The research objective of this proposal is to establish two high-precision optoelectronic lab-on-a-chips built with scalable fabrication process, aiming to offer high-content analysis at cellular and molecular levels towards next-generation precision therapeutics. Both lab-on-a-chips will be built in a highly scalable array form, with their precision being evaluated in cultured neuronal network and blood samples, respectively. The proposed work will open ample research opportunities in drug screening for neurological diseases and point-of-care testing for patients with acute immune symptoms. The intellectual merit of the proposed work will be evidenced by three major contributions: 1) a scalable, high-precision optoelectronic lab-on-a-chip capable of precise optogenetic control, electrical recording, and electrical field stimulation of neural activity; 2) a scalable, high-precision optoelectronic lab-on-a-chip capable of multiplexed on-chip fluorescence detection of biomarkers that are related to immune responses; and 3) drug-screening and immune response monitoring assays using these two lab-on-a-chips, which will shed light on therapeutics development targeted to neurological and autoimmune diseases.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

精确的治疗方法将获得特定于靶向患者的细胞/分子信息的生物医学设备。导致新的工程工具和与疾病相关的测定法，这将使该建议的教育目标是对侵害性筛查，免疫治疗性开发和护理系统的研究。 ，即服务点系统研究生在生物工程和医疗保健方面需要的劳动力需求；公民之间的生物技术和支持神经疾病的群体的研究目标。在高度可扩展的阵列中，将建立两个实验室的治疗方法。症状。 ;和3）使用两个实验室的药物筛选和IMUNE反应监测测定法，这将阐明对神经酚类学和自身免疫性疾病的治疗，这反映了NSF的奖项一个。

项目成果

Spectrally filtered photodiode pairs for on-chip ratiometric aptasensing of cytokine dynamics

• DOI: 10.1016/j.snb.2021.130330
• 发表时间: 2021-10
• 期刊: Sensors and Actuators B-chemical
• 影响因子: 8.4
• 作者: Z. Xiong;Kewei Ren;M. Donnelly;M. You;Guangyu Xu

Brushing-Assisted Two-Color Quantum-Dot Micro-LED Array Towards Bi-Directional Optogenetics

刷涂辅助双色量子点 Micro-LED 阵列实现双向光遗传学

• DOI: 10.1109/led.2021.3108554
• 发表时间: 2021
• 期刊: IEEE Electron Device Letters
• 影响因子: 4.9
• 作者: Mao, Dacheng;Xiong, Zheshun;Donnelly, Matthew;Xu, Guangyu
• 通讯作者: Xu, Guangyu

A Silicon Neural Probe Monolithically Integrated with 20 µm-Pitched Dual-Color Micro-Led Arrays

与 20 µm 间距双色 Micro-Led 阵列单片集成的硅神经探针

• DOI: 10.1109/mems58180.2024.10439308
• 发表时间: 2024
• 期刊: 2024 IEEE 37th International Conference on Micro Electro Mechanical Systems (MEMS
• 作者: Mao, Dacheng;Sun, Feng;Driscoll, Bradley;Li, Zhihao;Xu, Guangyu
• 通讯作者: Xu, Guangyu

Close-Packed PEDOT:PSS-Coated Graphene Microelectrodes for High-Resolution Interrogation of Neural Activity

密堆积 PEDOT:PSS 涂层石墨烯微电极用于神经活动的高分辨率检测

• DOI: 10.1109/ted.2021.3074353
• 发表时间: 2021
• 期刊: IEEE Transactions on Electron Devices
• 影响因子: 3.1
• 作者: Sun, Feng;Xiong, Zheshun;Park, Jinyoung;Xu, Guangyu
• 通讯作者: Xu, Guangyu